Compositions and method for treatment of cancer using monoclonal

Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin

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424 851, 424 858, 4352402, 43524021, 43524025, A61K 3702, A61K 3900, C12N 502

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051046520

ABSTRACT:
Cell surface gangliosides are presumed to play a role in cell growth and differentiation. Using monoclonal antibodies directed against G.sub.D3, a disialoganglioside expressed predominantly by cells of neuroectodermal origin, we have found that G.sub.D3 is expressed by a subpopulation of cells of the immune system including: a) fetal thymocytes in subcortical regions and near vessels, 2) lymph node lymphocytes in interfollicular areas and near vessels, and 3) a small subset of T cells in the peripheral blood. Mouse monoclonal antibodies (two IgGs, one IgM and F(ab').sub.2 fragments) reacting with G.sub.D3 were found to stimulate proliferation of T cells derived from peripheral blood. Proliferation induced by binding to G.sub.D3 could be augmented by exogenous IL-2, PMA, PHA or Protein A.

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Kasugi et al., Jpn, I Cancer Chemother. 11(8) 1984, pp. 1527-1537 (English translation).
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Honsik et al., PNAS, 10/86, pp. 7893-7897, vol. 83.
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