Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2000-08-17
2001-08-28
Henley, III, Raymond (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
06281222
ABSTRACT:
FIELD OF THE INVENTION
The invention relates to compositions and methods for treating or preventing acetaminophen intoxication.
BACKGROUND OF THE INVENTION
Acetaminophen is a mild analgesic and anesthetic that is safe and effective when ingested in therapeutic doses. Overdoses of acetaminophen, however, can lead to long-term health problems and can even be fatal. For example, overdoses of acetaminophen can lead to acute liver failure which may be associated with multi-organ failure, nephrotoxicity and occasionally pancreatitis. Acetaminophen intoxication can also occur in individuals with, e.g., impaired hepatic function, renal disease, chronic alcoholism, or malnutrition.
Damage caused by high doses of acetaminophen can manifest itself by elevated serum levels of the liver enzymes aspartate transaminase (AST) and alanine aminotransferase (ALT).
SUMMARY OF THE INVENTION
The invention is based in part on the discovery that inhibitors of the enzyme xanthine oxidase (XO) can be used to treat acetaminophen poisoning in a subject.
Accordingly, in one aspect the invention provides a method of treating tissue injury associated with ingestion of acetaminophen in a subject by administering to a subject in need thereof a pharmaceutically effective amount an inhibitor of xanthine oxidase.
Also within the invention is a method of preventing inflammation in a subject by administering to a subject at risk thereof a pharmaceutically effective amount an inhibitor of xanthine oxidase, wherein the inhibitor does not form a superoxide radical when introduced in the subject.
In another aspect, the invention includes a method of suppressing undesired free radical formation by administering to a subject in need thereof a pharmaceutically effective amount of an inhibitor of xanthine oxidase, wherein the inhibitor does not form a superoxide radical when introduced into the subject.
In a further aspect, the invention provides a method of enhancing survival in a subject suffering from acetaminophen intoxication by administering an inhibitor of xanthine oxidase in an amount sufficient to prolong survival of the subject.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In the case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and are not intended to be limiting.
Other features and advantages of the invention will be apparent from the following detailed description and claims.
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Mabley Jon
Salzman Andrew L.
Szabo Csaba
Henley III Raymond
Inotek Corporation
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
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