Compositions and method for treating affective, painful or...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

07629378

ABSTRACT:
Therapeutic compositions of doxepin and having a preponderance of the cis doxepin isomer over the trans doxepin isomer provide therapeutic effects for affective, painful, or allergic disorders without the sedative effects commonly experienced with compositions having a preponderance of the trans doxepin isomer.

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Arzneim-Fosch; “Plasma Levels of the Cis-and Trans-Isomers of Doxepin and Desmethyldoxepin after Administration of Doxepin tp Patents”, Drug Res.31, vol. 1, pp. 113-115, 1981.
USP25, 2002; United States Pharmacopeia Convention, Inc. Rockville, MD, p. 614.
Midha et al., “Steroselective pharmacokinetics of doxepin isomers.”, European Journal of Clinical Pharmacology (1992), 42(5), pp. 539-544.
Otsuki et al., “Comparison of Pharmacological Activities of Doxepin Hydrochloride with Its Geometrical Isomers,”Oyo Yakuri, 6 (5): 973-984 (1972) (Abstract).
Pinder et al., “Doxepin Up-to-date: A Review of its Pharmacological Properties and Therapeutic Efficacy with Particular Reference to Depression,”Drugs, 13: 161-218 (1977).
Ross, CRC Handbook of Stereoisomers: Drugs in Pharmacology, “Antidepressant Drugs:(Z)-and(E)-Isomers,” CRC Press, Boca Raton, Fla., pp. 243-255 (1984).
Yan et al., “Absolute bioavailability an stereoselective pharmacokinetics of doxepin,”Xenobiotica, 32 (7): 615-623 (2001).
International Search Report issued in PCT/US2003/36600 (2004).
Page 1 of Office Action issued in GB2411356 (2005).

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