Compositions and method for the treatment or prophylaxis of seps

Details Compositions and method for the treatment or prophylaxis of seps Compositions and method for the treatment or prophylaxis of seps

1989-01-24

1992-03-03

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

530380, 514921, A61K 3704, A61K 3700

Patent

active

050931172

ABSTRACT:
Pharmaceutical compositions useful for the treatment or prophylaxis of Gram-negative bacteremia or septic shock contain a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The compositions may further contain one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins.
A method for the treatment or prophylaxis of Gram-negative bacteremia or septic shock comprises administering, either together or separately, a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The method may optionally include administering one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins.

REFERENCES:
patent: 4587121 (1986-05-01), Collins et al.
Taylor et al., J. Clin. Invest. vol. 79 Mar. 1987 pp. 918-925.
Young et al., Abs. Clin. Res. vol. 30 No. 2, 1982 p. 522A.

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