Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1996-02-09
1999-03-16
Low, Christopher S.F.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
536 231, 536 241, 536 243, 435 6, 435 691, 4353201, 435455, C12N 1512
Patent
active
058829253
ABSTRACT:
The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease. Moreover, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of cardiovascular disease, and for monitoring the efficacy of compounds in clinical trials. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions.
REFERENCES:
patent: 5262311 (1993-11-01), Pardee et al.
patent: 5418162 (1995-05-01), Blakely et al.
patent: 5424187 (1995-06-01), Shor et al.
patent: 5545569 (1996-08-01), Grainger et al.
Papadaki et al. (Biotechnol. Prog., 13:209-221, 1997).
Ngo et al., in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al., (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Catalogue of Cell lines & Hybridomas, 7th Edition, 1992, p. v.
Hakes et al. (P.N.A.S., vol. 88, pp. 6186-6190, 1991).
Kanai et al. (Science, vol. 268, 12 May 1995).
Wallace et al, Methods in Enzymology (1987), 152:432.
Sambrook et al, Molecular Cloning, 1989, CSH:11.47.
Ledley. Hum. Gene Ther. 1995, 6:1129-1144.
Coghlan, New Scientist, Nov. 1995, vol. 148, pp. 14-15.
Marshall, Science, Aug. 1995:1053, vol. 270.
Farrow et al., 1995, "Cloning of bcl-2 homologue by interaction with adenovirus E1B 19K", Nature 374:731-733.
Kanai et al., 1995, "Identification and characterization of a prostaglandin transporter", Science 268:866-869.
Luscinskas et al., 1989, "Endothelial-Leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium", J. Immunol. 142:2257-2263.
Sekelsky et al., 1995, "Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster", Genetics 139:1347-1358.
Hochman et al., 1995, "Dissociation of Synchronization and Excitability in Furosemide Blockade of Epileptiform Activity", Science 270:99-102.
Grainger et al., 1995, "Tamoxifen elevates transforming growth factor-beta and suppresses diet-induced formation of lipid lesions in mouse aorta", Nature Medicine 1:1067-1073.
Gura, 1995, "Estrogen: Key player in heart disease among women", Science 269:771-773.
Grainger et al., 1993, "Proliferation of human smooth muscle cells promoted by lipoprotein(a)", Science 260:1655-1658.
Puolakkainen et al., 1993, "Serological response to Chlamydia pneumoniae in adults with coronary arterial fatty streaks and fibrolipid plaques", J. of Clinical Microbiol. 31:2212-2214.
Written Opinion, Related PCT Application No. PCT/US96/01883.
Wilson et al., 1994, "2.2 Mb of contiguous nucleotide ssequence from chromosome III of C. elegans", Nature 368:32-38.
Xu et al., 1994, "Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter", Proc. Natl. Acad. Sci. USA 91:2201-2205.
Yoshimura et al., 1994, "The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32", Gene 145:293-297.
W.M. Barnes, 1994, "PCR amplification of up to 35-kb DNA with high fidelity and high yield from .lambda. bacteriophage templates", Proc. Natl. Acad. Sci. USA 91:2216-2220.
Bevilacqua et al., 1989, "Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins", Science 243:1160-1165.
Bevilacqua et al., 1991, "Selectins: A family of adhesion receptors", Cell 67:233.
Black et al., 1994, "Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy on ovariectomized rats", J. Clin. Invest. 93:63-69.
Boise et al., 1993, "bcl-x, a bcl-2-Related gene that functions as a dominant regulator of apoptotic cell death", Cell 74:597-608.
Cercek et al., 1990, "Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation", Circulation Res. 66:1755-1760.
Cheng et al., 1994, "Effective amplification of long targets form cloned inserts and human genomic DNA", Proc. Natl. Acad. Sci. USA 91:5695-5699.
Cleary et al., 1986, "Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/Immunoglobulin transcript resulting from the t(14;18) translocation", Cell 47:19-28.
Coffman et al., 1990, "Xotch, the Xenopus homolog of Drosophila Notch", Science 249:1438-1441.
Cybulsky & Gimbrone, 1991, "Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis", Science 251:788-791.
Davies et al., 1986, "Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro", Proc. Natl. Acad. Sci. USA 83:2114-2117.
M.A. Gimbrone, 1976, "Culture of vascular endothelium" Progress in Hemostasis and Thrombosis Grune & Stratton Inc., NY, 3:1-28.
Gromadzinska & Sklodowska, 1990, "Erythrocyte glutathione peroxidase and myocardial infarction", JAMA 263:949-950.
Guidi et al., 1986, "Platelet glutathione peroxidase activity is impaired in patients with coronary heart disease", J. Clin. Lab Invest. 46:549-551.
Hakes & Berezney, 1991, "Molecular cloning of matrix F/G: A DNA binding protein of the nuclear matrix that contains putative zinc finger motifs", Proc. Natl. Acad. Sci. USA 88:6186-6190.
K. Heckl, 1988, "Isolation of cNDAs encoding human manganese superoxide dismutase", Nucl. Acids Res. 16:6224.
Hockenbery et al., 1993, "Bcl-2 functions in an antioxidant pathway to prevent apoptosis", Cell 75:241-251.
Jones et al., 1993, "Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines", J. Biol. Chem. 268:9049-9054.
Kita et al., 1987, "Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia", Proc. Natl. Acad. Sci. USA 84:5928-5931.
Kok et al., 1989, "Decreased selenium levels in acute myocardial infarction", JAMA 261:1161-1164.
Kumar & Chambon, 1988, "The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer", Cell 55:145-156.
Kume et al., 1992, "Lysophosphatidylcholine, a component of atherogenic lipoprotein, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells", J. Clin. Invest. 90:1138-1144.
Majesky et al., 1990, "PDGF ligand and receptor gene expression during repair of arterial injury", J. Cell Biol. 111:2149-2158.
Malden et al., 1991, "The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages", J. Biol. Chem. 266:13901-13907.
Nagel et al., 1994, "Shear stress selectively upregualtes intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells", J. Clin. Invest. 94:885-891.
Navab et al., 1988, "Monocyte migration into the subendothelial space of a coculture of adult human aortic endothelial and smooth muscle cells", J. Clin. Invest. 82:1853-1863.
Ohno et al., 1994, "Gene therapy for vascular smooth muscle cell proliferation after arterial injury", Science 265:781-784.
Oltvai et al., 1993, "Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates
Low Christopher S.F.
Millennium Pharmaceuticals Inc.
Nguyen Dave Trong
LandOfFree
Compositions and method for the treatment and diagnosis of cardi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and method for the treatment and diagnosis of cardi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and method for the treatment and diagnosis of cardi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-816781