Compositions and method for inhibition of HIV production

Details Compositions and method for inhibition of HIV production Compositions and method for inhibition of HIV production

1991-04-15

1994-04-26

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4352402, 4353201, 935 56, 935 71, C12N 1500, C12N 500

Patent

active

053066316

ABSTRACT:
A method for the selective killing of HIV-infected cells, via HIV-regulated expression of a toxin gene, is provided in the present invention. Specifically, the expression of the diphtheria toxin fragment A gene is subject to tight control by cis-acting HIV regulatory sequences and trans-acting regulatory factors. Also provided is a method of protecting a host from HIV infection by the stable transformation of target cells, those cells which can be infected with HIV, with an HIV-regulated toxin gene. When such a stably transformed cell becomes infected with HIV, induction of the toxin gene prevents the replication and spread of the virus.

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