Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1984-02-24
1988-05-17
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 56, 514 54, 514822, A61K 3700, A61K 31725, A61K 31715
Patent
active
047450983
ABSTRACT:
The healing of wounds is promoted by contacting the wound surfaces with a suspension of collagen and a glycosaminoglycan that is chemotactic for fibroblasts and/or endothelial cells. Typical glycosaminoglycans that exhibit the desired chemotaxis are heparin, heparan sulfate, and alginate. Two or more glycosaminoglycans can be present in the suspensions. Collagen is present in the suspension in the order of 7-10 mg/ml; while the glycosaminoglycan is present in much lower concentrations, e.g., 250-350 .mu.g/ml. Application of the collagen/glycosaminoglycan suspension to open wounds greatly increases the rate of healing.
REFERENCES:
patent: 4060081 (1977-11-01), Yannas et al.
patent: 4350629 (1982-09-01), Yannas et al.
patent: 4418691 (1983-12-01), Yannas et al.
patent: 4448718 (1984-05-01), Yannas et al.
Yannas et al., Stage 2 Artificial Skin: A Polymeric Template for Regeneration of New Skin, Chem Abstracts 99: 110713m (1982).
Danielsen, Mechanical Properties of Reconstituted Collagenfibrils, Influence of a Glycosaminoglycan: Dermatan Sulfate, Chem Abstracts 98:1845q (1982).
Yannas et al., Design Principles and Preliminary Clinical Performance of an Artificial Skin, Chem Abstracts 97: 115299z (1982).
Jungneira et al., Correlation of Specific Sulfated Glycosaminoglycans with Collagen Types I, II and III, Chem Abstracts 95:21810r (1981).
Gallagher et al., Synthesis of Glycosaminoglycans by Human Skin Fibroblasts Cultured on Collagen Gels, Chem Abstracts 93: 235868y (1980).
Dagalakis et al., Design of an Artificial Skin, Part III, Control of Pore Structure, Chem Abstracts 93: 225595t (1980).
Stryer: Biochemistry (2nd ed.), pp. 200-203 (1981).
Nature 297:307, 1982; S. Taylor et al., "Protamine is an Inhibitor of Angiogenesis".
Science 721:719, 1983; J. Folkman et al., "Angiogenesis Inhibition Caused by Heparin in the Presence of Cortisone".
Journ. of Biomed. Materials Research 14:511 1980--N. Dagalakis et al., "Design of an Artificial Skin".
Technology Review-May/Jun. 1981; pp. 79-81.
Ann. Surgery 194:413 1981; J. Burke et al.
Journ. of Biomed. Materials Research 14:107-1980, I. Yannas et al.
Journ. of Biomed. Materials Research 14:65--1980; I. Yannas et al.
Cancer Research 43:1790--1983--G. Alessandri et al.
J. Clinical Investigations 62:916 et seq. 1978 T. M. Chiang et al.
Brown J. R.
Rollins John W.
The Regents of the University of California
LandOfFree
Compositions and method for improving wound healing does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and method for improving wound healing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and method for improving wound healing will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1881449