Compositions and method for enhancement of the transdermal flux

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only

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604896, 514653, 514588, 514202, A61K 900, A61K 3155, A61K 31135

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active

046997776

ABSTRACT:
A topical albuterol composition having superior transdermal flux containing various amounts of albuterol, 1-dodecyl-azacycloheptan-2-one and urea in a non-aqueous environment. The enhancement observed in albuterol skin penetration indicates that a therapeutically effective amount of albuterol can be delivered through skin using these formulations. The compositions can be administered topically as a cream, lotion or via a transdermal device.

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Stoughton, Azone.RTM. (1-Dodecyl-Azacycloheptan-2-one) Enhances Percutaneous Penetration, III International Symposium on Psoriasis, Stanford, (Jul. 13-17, 1981).
Allenby et al., Brit. J. Dermatol., 81, Suppl. (4) 47-55 (1969).

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