Compositions and method comprising heterocyclic compounds contai

Details Compositions and method comprising heterocyclic compounds contai Compositions and method comprising heterocyclic compounds contai

1987-01-12

1989-10-24

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

A61K 3158

Patent

active

048762490

ABSTRACT:
A method and compositions for topically administering physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for systemic use or to the skin of humans and animals for localized use comprising applying to such skin or membrane a mixture of said physiologically active agent and a non-toxic, effective penetrating amount of penetration enhancing compound having the structural formula I: ##STR1## wherein: R is a saturated or unsaturated hydrocarbon group with from 5 to 19 carbon atoms; R' and R" are hydrogen, lower alkyl, trifluoromethyl, lower hydroxyalkyl or lower alkyl ester of lower hydroxyalkyl, with the proviso that both R' and R" are not lower hydroxyalkyl; X is O or NR.sub.1 ; R.sub.1 being hydrogen, lower alkyl, lower alkenyl, lower hydroxyalkyl or lower alkyl ester of lower hydroxyalkyl are disclosed.

REFERENCES:
patent: 4282216 (1981-08-01), Rovee et al.
patent: 4473565 (1984-09-01), Rovee et al.

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