Compositions and formulations of 9-nitrocamptothecin...

Details Compositions and formulations of 9-nitrocamptothecin... Compositions and formulations of 9-nitrocamptothecin...

2006-07-04

2006-07-04

Hartley, Michael (Department: 1618)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S279000, C424S464000

Reexamination Certificate

active

07071202

ABSTRACT:
A polymorphic form of 9-nitrocamptothecin is provided, the polymorph being characterizable as having, by differential scanning calorimetry, no observable endotherm and an exotherm at between 273.6 and 275.6° C., and a solution NMR spectrum with multiplets at 1.7 and 3.7 ppm shifts.

REFERENCES:
patent: 5162532 (1992-11-01), Comins et al.
patent: 5922877 (1999-07-01), Cao
patent: 6288072 (2001-09-01), Wall et al.
patent: 6291676 (2001-09-01), Burke et al.
patent: 6482830 (2002-11-01), Redkar et al.
patent: 6492379 (2002-12-01), Redkar et al.

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