Compositions and devices for partitioning advanced glycosylation

Details Compositions and devices for partitioning advanced glycosylation Compositions and devices for partitioning advanced glycosylation

1996-04-05

1999-04-06

Weber, Jon P.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210645, 530811, 530812, 530815, 435 2, B01D 1104, A01N 102

Patent

active

058913416

ABSTRACT:
The present invention is directed to compositions and devices based upon the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions and devices having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

REFERENCES:
Knibbs et al. (1993) J. Biol. Chem. 268:14940-7.
Li et al. (1995) Nature Medicine 1:1057-61.
Schmidt et al. (1995) Nature Medicine 1:1002-4.
Talor et al. (1995) Clin. Exp. Immunol. 102:406-16.
Moshchin'ski et al. (1990) Lab Delo (USSR)(6):57-60 (Medline Abstract).
Moszczyniski et al. (1990) Pol. Arch. Med. Wewn. (Poland) 83(4-6):194-9 (Medline Abstract).
Thompson et al. (1990) J. Lab. Clin. Med. 115:148-58 (Medline Abstract).
Wagnerova et al. (1988) J. Hyg. Epidemiol. Microbiol. Immunol. (Czechoslovakia) 32(3):265-272 (Medline Abstract).
Olson et al. (1985) J. Dent. Res. 64(5):826-30 (Medline Abstract).
Wagnerova et al. (1986) Czeh. Med. 9(4):210-7 (Medline Abstract).
Wagner et al. (1987) Czeh. Med. 10(2):70-8 (Medline Abstract).
Moszczyniski, P. (1992) Wiad. Lek. (Poland) 45(4-6):180-4 (Medline Abstract).
Moszczyniski et al. (1991) Gig. Tr. Prof. Zabol. (USSR) 3:34-6 (Medline Abstract).
Moszczyniski et al. (1991) Pneumonol. Alergol. Pol. (Poland) 59:17-21 (Medline Abstract).

Affiliated with

Also associated with

Rating

Compositions and devices for partitioning advanced glycosylation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and devices for partitioning advanced glycosylation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and devices for partitioning advanced glycosylation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1368221