Compositions

Details Compositions Compositions

1995-01-23

1998-02-03

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5462737, C07D40112, A61K 3144

Patent

active

057145040

ABSTRACT:
The novel optically pure compounds Na.sup.+, Mg.sup.2+, Li.sup.+, K.sup.+, Ca.sup.2+ and N.sup.+ (R).sub.4 salts of benzimidazole or benzimidazole, in particular sodium and magnesium salt form thereof, where R is an alkyl with 1-4 carbon atoms, processes for the preparation thereof and pharmaceutical preparations containing the compounds as active ingredients, as well as the use of the compounds in pharmaceutical preparations and intermediates obtained by preparing the compounds.

REFERENCES:
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Cairns, et al. "Enantioselective HPLC determination . . . " Journal of Chromatography 8,666 (1995) 323-328.
Yamada et al. "Synthesis and isomerization of optical active . . . " Chem. Pharm. Bull. 42(8) (1994) 1679-1681.
K. Miwa et al. Jpn. Pharmacol. Ther. "Proton pump inhibitor in rats, mice and dogs" 18 (1990) 165-187 (transl).
H. Katsuki et al. "Determination of R(+)-and S(-)-Lansoprazole" Pharmaceutical Research 13(4) (1996) 611-615.
M. Tanaka et al. "Direct determination of pantoprazole enantiomers . . . " Anal. Chem. 68 (1996) 1513-1516.
P. Lindberg et al. "Omeprazole: The first proton pump inhibitor" Medicinal Res. Rev. 10 (1990) 2-50.
P. Lindberg et al. "The mechanism of action of . . . omeprazole" Journal of Medicinal Chemistry 29 (1986) 1327.
A. Brandstrom "Chemical reactions . . . " Reprint from Acta Chemica Scandinavica 43 (1989) 536-611.
K. Sigrist-Nelson et al. "Ro 18-5364, a potent inhibitor of the gastric (H.sup.+ +K.sup.+)-ATPase" Eur. J. Bioch. 166 (1987) 453.
Polomomcoll et al. CA 117;90292, 1992.

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