Drug – bio-affecting and body treating compositions – Face or body powders for grooming – adorning – or absorbing
Reexamination Certificate
1999-08-13
2001-04-24
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Face or body powders for grooming, adorning, or absorbing
C424S401000
Reexamination Certificate
active
06221346
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a composition containing cetyl alcohol, coconut oil, polyoxyethylene oleo-linoleic glyceride, possibly water, and possibly other additives and/or pharmaceutically active principle(s).
2. Description of the Prior Art
A fatty composition containing cetyl alcohol, a fraction of coconut oil and other additives is known by WO 91/01717. This composition is suitable to be mixed with a large amount of an aqueous phase.
However this composition is not suitable for being mixed with essential oils or with preparations containing paraffin or propylene glycol. Furthermore, the aqueous phase of said document has to contain specific additives and has to be heated before being mixed with the fatty phase.
SUMMARY OF THE INVENTION
The present invention relates to a composition containing advantageously one or more active principles and advantageously free of water, which is suitable to be mixed with water with or without additives, for forming a cream or a stable lotion. The composition according to the invention is moreover very stable on a long period of time and allows to avoid degradation of the active principle or agent due to its contact with water during the storage of the composition. The composition of the invention is thus suitable for preparing a cream or a lotion containing the active agent just before its use. Finally, the composition according to the invention, especially when the composition is substantially water free, has an excellent resistance against the rancid growing, even if the composition contains whole or entire coconut oil, and not a specific fractionated coconut oil known under the name Miglyol, fractionated oil known for having a better resistance against the rancid growing than whole (not fractionated) coconut oil.
The composition according to the invention contains a specific additive, namely polyoxyethylene glyceride, i.e. the product of the alcoholysis of a natural vegetal oil by polyoxyethylene glycols. The said additive is in particular a polyoxyethylene oleo-linoleic glyceride or the product of an alcoholysis of a natural corn oil by polyoxyethylene glycols. The composition according to the invention is thus a composition containing cetyl alcohol, coconut oil, polyoxyethylene oleo-linoleic glyceride, possibly water, and possibly other additives and/or pharmaceutically active principle(s), said composition containing in % of dry matter:
5 to 15% polyoxyethylene oleo-linoleic glyceride, and
20 to 40% cetyl alcohol,
the weight ratio coconut oil and other additives and/or pharmaceutically active principle(s) or agent(s)/cetyl alcohol being comprised between 2/1 and 80/15. This weight ratio is important for obtaining a good stability of the composition, in particular after addition of an important amount of water.
Preferably, the weight ratio coconut oil and other additives and/or pharmaceutically active principle(s)/cetyl alcohol is comprised between 2/1 and 70/25. According to a particularly advantageous manner, the ratio is comprised between 2.1 and 2.45. According to an embodiment, the composition according to the invention contains in % of dry matter:
5 to 10% polyoxyethylene oleo-linoleic glyceride, and
20 to 35% cetyl alcohol.
Advantageously, the composition according to the invention is prepared without water or substantially without water, the water necessary for its use being added just before its use. The composition contains for example less than 5% by weight water and has the form of a powder suitable to be mixed with an aqueous phase for forming a milk or cream. Preferably, the powder has a particle size lower than 500 &mgr;m, preferably lower than 100 &mgr;m.
According to an embodiment, the composition contains 5 to 95% by weight water, for example 5 to 50% by weight water.
The composition according to the invention contains advantageously one or more pharmaceutically active principles, in the form of essential oil, alcohol extract or hydro-alcohol extract, chlohexidri gluconas, liquid extract, preparation containing propyleneglycol, preparation containing paraffin, preparation containing glycerin soaking product, or a mixture thereof.
The composition according to the invention may contain, in % of dry matter, up to 75% of pharmaceutically active principle(s) or agent(s). As the composition according t the invention can have the form of a powder and as the active principle(s) or agent(s) are advantageously distributed on a homogeneously manner in the powder, the composition can be packed in sachets or bags containing one dose of the active agent(s).
The invention relates also to a process for the preparation of a powder containing at least a pharmaceutically active principle or agent, the said powder being intended to be mixed with an aqueous medium for giving a cream or a milk. In said process:
cetyl alcohol, coconut oil, polyoxyethylene oleo-linoleic glyceride and possibly other additives are mixed in liquid form (for example after heating and melting of the products in solid form at ambient temperature) so as to form a mixture containing less than 5% water,
the said mixture is transformed into a powder, and
the said powder is mixed with one or more pharmaceutically active agents, and possibly with other additives.
According to an embodiment, the mixture is transformed into a powder after cooling and solidification of the mixture.
According to another possible embodiment, the mixture is transformed into a powder by spraying the mixture in an atmosphere, the temperature of which is lower than the solidification temperature.
Advantageously, the amount of coconut oil is adjusted so that the powder has a weight ratio coconut oil and other additives and/or pharmaceutically active principle(s) or agent(s)/cetyl alcohol comprised between 70/25 and 2/1.
According to embodiments, polyoxyethylene oleo-linoleic glyceride and cetyl alcohol are used in amounts such that the powder contains in % of dry matter:
5 to 10% polyoxyethylene oleo-linoleic glyceride, and
20 to 35% cetyl alcohol.
According to an embodiment, the mixture is transformed into a powder with a particle size lower than 500 &mgr;m, preferably lower than 100 &mgr;m, for example lower than 50 &mgr;m.
Preferably, in a first step, a liquid mixture containing cetyl alcohol, coconut oil, and possibly one or more additives, and in a second step, one or more pharmaceutically active principles or agents premixed with polyoxyethylene oleo-linoleic glyceride, are added to the liquid mixture prepared in the first step.
It would also be possible to prepare, in a first step, a liquid mixture containing cetyl alcohol, coconut oil, polyoxyethylene oleo-linoleic glyceride, and possibly one or more additives, and, in a second step, one or more pharmaceutically active principles are added in liquid form to the liquid mixture prepared in the first step.
For example, one or more pharmaceutically active principles, in the form of essential oil, alcohol extract or hydro-alcohol extract, chlohexidri gluconas, liquid extract, preparation containing propyleneglycol, preparation containing paraffin, preparation containing glycerin soaking product, or a mixture thereof, are used.
REFERENCES:
patent: 4929439 (1990-05-01), Cotteret et al.
patent: 5104656 (1992-04-01), Seth et al.
patent: 5472982 (1995-12-01), Suzuki
patent: WO91/101717 (1991-02-01), None
Dodson Shelley A.
George Konata M
Hovey Williams Timmons & Collins
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