Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1986-09-24
1989-08-29
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
264 41, 264 43, 264 46, 424450, 4284022, 436829, 514458, 514913, 549410, A61K 31355, A61K 4300, C07D31172
Patent
active
048615803
ABSTRACT:
Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.
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Bergamini Michael V. W.
Bolcsak Lois E.
Janoff Andrew S.
Suddith Robert L.
Tremblay Paul A.
Bloom Allen
Kurtz Catherine L.
Lovering Richard D.
The Liposome Company Inc.
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