Composition providing a lasting cosmetic and/or pharmaceutical t

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

Patent

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Details

424497, 424 7803, 4284022, 42840221, 264 41, 264 46, 514937, 514938, 514939, A61K 748

Patent

active

059938315

DESCRIPTION:

BRIEF SUMMARY
The present invention relates to a composition providing a lasting cosmetic and/or pharmaceutical treatment of the upper epidermal layers by topical application on the skin.
The application to the skin of oils active per se and/or containing an active ingredient has long been known in the cosmetic and/or pharmaceutical fields. These oils can be used as they are; they are most often in the form of a water-in-oil or oil-in-water emulsion. They may also, in a known manner, be applied encapsulated in microcapsules of gelatin or of other polymers which are crushed on the skin so as to release the oils, these microcapsules being, in general, between 5.times.10.sup.4 and 2.times.10.sup.6 nanometres in size (see for example U.S. Pat. No. 4,976,961). But the oils applied remain for the most part at the surface of the skin where they can be rapidly removed simply by rubbing, for example, upon contact with clothing, or by washing.
Moreover, there are known, by the name of nanoparticles, colloidal particles which are much smaller in size than microparticles since their size is generally of the order of 10 to 1000 nm; in these nanoparticles, an active ingredient is trapped by encapsulation and/or by adsorption and/or absorption (see J. Keuter, J. microencapsulation 1988 Vol. 5, pages 115-127). The term nanoparticles is generic and covers, on the one hand, nanospheres and, on the other hand, nanocapsules; the term "nanospheres" designates nanoparticles consisting of a porous polymeric matrix on which the active ingredient is absorbed and/or adsorbed and the term "nanocapsules" designates the nanoparticles consisting of a polymeric membrane surrounding a core formed by the active ingredient. The polymers which can be used for the manufacture of nanocapsules may be, in a known manner, either biodegradable materials or nonbiodegradable materials.
In French Patent Application 90,034,418, the applicant described a cosmetic composition for topical application containing nanocapsules of biodegradable polymer encapsulating an oily phase which contains an active ingredient. The applicant has found that the nanocapsules penetrate into the skin and release their contents for the most part into the epidermis; the nanocapsules being of biodegradable polymer, they are rapidly degraded in the epidermis by the action of the enzymes present therein and release the oily phase which they contain. In this composition, the oily phase, being released in situ in the epidermis, can therefore no longer be removed simply by rubbing or by washing. The active ingredient has an immediate maximum effect, which is advantageous in many treatments where an immediate activity is desired, such as anti-inflammatory treatments.
But in a number of cosmetic and/or pharmaceutical treatments, it is desired that the active ingredients should have a prolonged action over time without the need for the application to be repeated too frequently. Such is the case for example for protecting the skin with sunscreen agents, for the direct coloring of the skin with colorants or pigments and for treating the skin with deodorants, humectants or free radical-capturing agents.
According to the present invention, it was found that a composition containing nanocapsules could be obtained, in which composition the active ingredients have a prolonged action over time, using nanocapsules of a nonbiodegradable polymer.
The subject of the present invention is therefore a composition providing a cosmetic and/or pharmaceutical treatment of the upper epidermal layers by topical application to the skin, each application preferably needing to have a prolonged effect over time, characterised by the fact that it comprises, in a suitable carrier, nanocapsules of nonbiodegradable polymer(s) encapsulating an oily phase containing at least one active oil and/or at least one active ingredient in an active oil, the nanocapsules being between 100 and 1000 nm, preferably between 200 and 800 nm, in size.
At least one of the active ingredients is preferably chosen from those which need to have a la

REFERENCES:
patent: 3965033 (1976-06-01), Matsukawa et al.
patent: 5049322 (1991-09-01), Divissagvet et al.

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