Composition of matter comprising an imprinted matrix exhibiting

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

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435 2, 435 4, 435 34, 435 721, 435 723, 4352402, 4352351, 530350, 530395, A01N 102, C12Q 170, C12Q 104, C12N 500

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053106482

ABSTRACT:
The invention provides an imprinted matrix which exhibits selective binding interactions through metal chelates with a predetermined molecule or biological particle. Also provided is a preformed, fluid-imprinted matrix having sufficient rigidity to maintain selective binding interaction with a predetermined molecule or biological particle through interactive moieties. Methods for producing such matrices are additionally provided.

REFERENCES:
Dodrer, N. and Regen, S., "Polymerized Liposomes Designed to Probe and Exploit Ligand-Receptor Recognition at the Supramolecular Level", J. Am. Chem. Soc. 112 2829-2830 (1990).
Day, D. et al., "Polymerization of Mono- and Bi-functional Diacetylene Derivatives in Monolayers at the Gas-Water Interface", Israel Journal of Chemistry: 18 325-329 (1979).
Fuhrhop, J. and Mathieu, J., "Routes to Functional Vesicle Membranes without Proteins", Angew. Chem. Int. Ed. Engl.:23 100-112 (1984).
Porath, Jerker et al., "Metal chelate affinity chromatography, a new approach to protein fractionation", Nature 258:598-599 (1975).
Gunter Wulff, "Molecular Recognition in Polymers Prepared by Imprinting with Templates", ACS Symp. Ser. 308, 186-230 (1986).
Ekberg, B. and Mosbach, K., "Molecular imprinting: a technique for producing specific separation materials", Tibtech 7:92-96 (1989).

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