Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1990-06-28
1992-01-28
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530402, 530403, 530404, 530405, 424 851, 424 8591, 514 2, 514 8, A61K 3702
Patent
active
050845560
ABSTRACT:
A composition and method for treating cancers characterized by over-expression of the c-fms proto-oncogene/M-CSF receptor protein are provided. The composition involves a M-CSF polypeptide cross-linked to a cytotoxic agent capable of crossing into the cytoplasm of the cell bearing the receptor and killing the cell.
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Marimato et al., J. Immunol 131, 1983, pp. 1726-1764.
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Cserr Luann
Draper Garnette D.
Eisen Bruce
Genetics Institute Inc.
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