Composition of intravenous immune globulin

Details Composition of intravenous immune globulin Composition of intravenous immune globulin

1983-09-02

1984-11-13

Shapiro, Lionel M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112B, 424 85, 424 87, A23J 0000, C07G 700, C09H 0000, A61K 3900

Patent

active

044824831

ABSTRACT:
An intravenous immune globulin preparation having at least 99% pure globulin protein and an anticomplement activity of less than 0.10 C'50 units/mg IgG prepared by: precipitating impurities from Cohn Fraction II in an aqueous-alcohol medium at defined temperature and pH, removing the precipitated impurities, stabilizing the diluted solution with albumin, concentrating the solution and removing the alcohol therefrom. Also prepared by this method, an intravenous, hyperimmune globulin preparation having increased antibody titers to sixteen serospecific strains of Pseudomonas aeruginosa.

REFERENCES:
patent: 4021540 (1977-05-01), Pollock et al.
patent: 4165370 (1979-08-01), Coval
patent: 4168303 (1979-09-01), Nishida et al.
patent: 4276283 (1981-01-01), Eibl et al.
patent: 4296027 (1981-10-01), Condie

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