Composition of immunotoxins with interleukin-2

Details Composition of immunotoxins with interleukin-2 Composition of immunotoxins with interleukin-2

1987-05-29

1990-01-16

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 424 858, 424 8591, 514 2, 514 8, 514 21, 514885, 530351, 530389, 530391, A61K 3702

Patent

active

048942278

ABSTRACT:
Anti-tumor activity in humans can be augmented by administering to the mammalian host a pharmacologically effective amount of mammalian IL-2 and at least one immunotoxin that binds selectively to human tumor cells. The IL-2 and immunotoxin are preferably administered separately to the host. The composition is useful for prophylactic or therapeutic treatment of such cancers as ovarian and breast cancer.

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Perez et al., J. Immunol., 137: 2069-2072, (1986).
Perez et al., J. Exp. Med., 163: 166-178, (1986).

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