Composition of immunotoxins and retinoids and use thereof

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugate includes potentiator; or composition comprising...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4241831, 4241791, 4241801, 4241811, A61K 39395

Patent

active

059422300

ABSTRACT:
The present invention relates to compositions of retinoids plus immunotoxins. More particularly this invention relates to the use of retinoids to potentiate the activity of immunotoxins for treatment of mammalian diseases.

REFERENCES:
patent: 4894227 (1990-01-01), Stevens et al.
patent: 5112607 (1992-05-01), Hudson et al.
Dermer, G.B. "Another anniversary for the war on Cancer" Bio/Technology, vol. 12, p. 320, Mar. 12, 1994.
Fowler et al. "Combined preoperative and postoperative immunotherapy for murine c1300 neuroblastoma" J. of Pediatric Surg. vol. 28, No. 3, pp. 420-427, 1993.
Bollag, W. "Retinoids and cancer" Cancer Chemother. Pharmacol. vol. 3, pp. 207-215, 1979.
Rybak, et al., "Clinical Use of Immunotoxins, Monoclonal Antibodies Conjugated to Protein Toxins", (1991), Immunology and Allergy Clinics of North America, vol. 11, No. 2, 359-380.
Thorpe, et al. "Improved Antitumor Effects of Immunotoxins Prepared With Deglycosylated Ricin A-Chain and Hindered Disulfide Linkages", (1988), Cancer Research, vol. 48, 6396-6402.
Vitetta, et al., "Redesigning Natures's Poisons to Create Anti-Tumor Reagents", (1987), Science, vol. 238, 1098-1104.
Pastan, et al., "Immunotoxins", (1988), Cell , vol. 47, 641-648.
Blakey, et al., "Comparison of the Pharmacokinetics and Hepatotoxic Effect of Saporin and Ricin A-Chain Immunotoxins on Murine Liver Parenchymal Cells", (1988), Cancer Research, vol. 48, No. 24, 7072-7078.
Laurent, et al., "Effects of Therapy with T101 Ricin A-Chain Immunotoxin in Two Leukemia Patients", (1986), Blood, vol. 67, No. 6, 1680-1697.
Grossbard, et al., "Serotherapy of B-cell Neoplasms With Anti-B4-Blocked Ricin: A Phase I Trial Of Daily Bolus Infusion", (1992) Blood, vol. 79, No. 3, 575-585.
Wu et al., (ABSTRACT) "Retinoic Acid Alters Cellular Traffic and Potentiates Immunotoxins" (1994) Proc. of the American Association for Cancer Research, Vol. 35:503, Abstract #2996.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Composition of immunotoxins and retinoids and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Composition of immunotoxins and retinoids and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition of immunotoxins and retinoids and use thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-464339

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.