Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2002-10-08
2004-08-24
Tate, Christopher R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Reexamination Certificate
active
06780441
ABSTRACT:
TECHNICAL FIELD
This invention relates to a new herbal formulation which has been found to be effective for the treatment of cancer. More particularly, the formulation can be used to treat squamous cell carcinomas, tumours and other metastatic states, including lung cancer.
The conventional treatment of tumerous cancers, including lung cancer, comprises surgery, chemotherapy and/or radiotherapy. The drugs given during chemotherapy are of necessity very powerful and, in consequence, can have serious and undesirable side-effects. There is therefore a need for improved pharmaceutical or medicinal preparations for use in the treatment of cancer. It is the object of this invention to provide such a product.
According to this invention there is provided a pharmaceutical or medicinal preparation which comprises a mixture of the following eleven herbs:
Withania somnifera, Chlorphyton borivilianum, Boerhavia diffusa, Elephantopus scaber, Moringa oleifera, Tecoma undulata, Bauhinia purpurea, Ficus racemosa, Cyperus rotundus, Sphaeranthus acmella
and
Tinospora cordifolia
or a mixture of the active ingredients that have been extracted from those herbs or chemically synthesized. This product has been found by the inventor to be particularly effective for the treatment of lung cancer, including all types of bronchogenic carcinomas and pleural malignancies. The preparation is preferably formulated for administration to patients as a liquid or syrup, but could also be administered as a capsule or tablet.
The ingredients for a typical herbal formulation according to this invention are set out in Table I. It should be appreciated that the proportions of the individual herbs may be varied and the figures quoted in Table I are by way of illustration only. In particular, the proportions of one or more of the components may be varied in order to optimize the pharmacological effects produced by the formulation to suit the specific needs of patients being treated.
It is an important feature of the product of the present invention that it contains a mixture of herbs, or extracts from herbs, rather than being based on a single herb. A synergistic effect has been noticed between the various ingredients. The herbs when exhibited unexpected synergistic property. The activities of similar herbs are combined to optimize and enhance the pharmacological effects without increasing the adverse toxic reactions (which becomes a distinct possibility if the herbs are used singly in a concentration of 100%). The advantage of a multi-drug regimen also lies in the fact that the possibility of development of drug resistance is minimized.
Preliminary clinical trials of the product of this invention have produced definite clinical evidence of improvement in the condition of patients suffering from lung cancer. These improvements include:
i) reduction in the tumour size as noted on X-ray, ultra sonography, C.T. Scan and MRI.
ii) improvement in the relevant biochemical parameters; and
iii) disappearance of malignant cells from sputum and pleural fluid;
and more subjectively:
i) sense of well being,
ii) improvement in appetite, and
iii) increased vigour and enthusiasm in daily activities.
The formulation of this invention is itself effective for the treatment of cancer. It may also be used as an adjuvant to conventional modes of anticancer therapy, namely radiotherapy and/or chemotherapy. The formulation may be presented as a dietary supplement for patients diagnosed as having any type of cancer. It may also be used to create a sense of general well being and to increase the vitality in patients diagnosed as having any type of cancer, to increase the appetite, restore health and increase the lifespan of patients diagnosed as having any type of cancer; to improve the ambulatory capacity in patients diagnosed as having any type of cancer; to activate the nervous system, prevent degenerative changes, stimulate regeneration and improve the psychological status in patients diagnosed as having any type of cancer, and to stimulate metabolism, accelerate anabolism, promote catabolism thereby flushing the body of toxic metabolites and reducing the side effects of chemotherapy and radiotherapy. The hepatic clearance of substances like iron and ferritin in cases of thalassemia is also improved, thereby reducing the iron overload in such cases.
The manufacture of a product according to the present invention will now be illustrated by the following example. However, it will be appreciated that the active ingredients may be chemically synthesised as an alternative to being extracted from the natural herbs.
REFERENCES:
patent: 7304685 (1995-11-01), None
patent: 9108750 (1991-06-01), None
patent: 9418993 (1994-09-01), None
De Silva et al., “A New Sesqui Terpene Lactone From Elephantopus-Scaber,” 1982 Phytochemistry (Oxford) vol. 21, No. 5, pp. 1173-1175.
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Sohn et al., “Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies,” 1996, Journal of Ethnopharmacology, vol. 54, No. 2-3, pp. 119-124.
Kapil et al., “Immunopotentiating compounds fromTinospora cordifoia,” 1997 Journal of Ethnopharmacology, Elsevier Scientific Publishers Ltd., IE, pp. 89-95.
Menon et al., “Effect of rasayanas in the inhibition of lung metastasis induced by B16f-10 melanoma cells,” Dec. 1997, Journal of Experimental & Clinical Cancer Research, vol. 16, No. 4, pp. 365-368.
Jagetia et al., “Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in cultured HeLa cells” 1998, Cancer Letters, vol. 127, pp. 71-82.
Praveen et al., “Effect of “Rasayanas” a herbal drug preparation on cell-mediated Immune responses in tumour bearing mice,” Jan. 1999, Indian Journal of Experimental Biology, vol. 37, No. 1, pp. 23-26.
Tsai et al., “Anti-inflammatory effects of Taiwan folk medicine ‘Teng-Khia-U’ on carrageenan-and adjuvant-Induced paw edema in rats,”, Jan. 1999, Journal of Ethnopharmacology, vol. 64, No. 1, pp. 85-89.
Leemol et al., “Effect ofWithania somniferaon cytokine production in normal and cyclophosphamide mice,” Nov. 1999, Immunopharmacology and Immunotoxicology, vol. 21, No. 4, pp. 695-703.
Mandal et al., “Anti-inflammatory evaluation ofFicus racemosaLinn. leaf extract.” Sep. 2000, Journal of Ethnopharmacology, Ireland, Sep. 2000, vol. 72, No. 1-2 pp. 87-92.
Sahajanand Biotech Private Limited
Tate Christopher R.
Volpe and Koenig P.C.
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