Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-10-20
1999-12-14
Jagannathan, Vasu S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424 851, 530350, 530351, A61K 3804, A61K 3819, C07K 14525, C07K 14535
Patent
active
060018038
ABSTRACT:
A pharmaceutical composition which comprises the c-kit ligand (KL) purified by applicants or produced by applicants' recombinant methods in combination with other hematopoietic factors and a pharmaceutically acceptable carrier is provided as well as methods of treating patients which comprise administering to the patient the pharmaceutical composition of this invention. This invention provides combination therapies using c-kit ligand (KL) and a purified c-kit ligand (KL) polypeptide, or a soluble fragment thereof and other hematopoietic factors. It also provides methods and compositions for ex-vivo use of KL alone or in combination therapy. A mutated KL antagonist is also described. Such an antagonist may also be a small molecule. Antisense nucleic acids to KL as therapeutics are also described. Lastly, compositions and methods are described that take advantage of the role of KL in germ cells, mast cells and melanocytes.
REFERENCES:
patent: 5199942 (1993-04-01), Gillis
patent: 5399493 (1995-03-01), Emerson
patent: 5409825 (1995-04-01), Hoffman
Anderson, D.M. Molecular Cloning of Mast Cell Growth Factor, a Hematopoietin That Is Active In Both Membrane Bound And Soluble Forms. Cell (1990) 63:235-243 (Exhibit 8).
Bazan, J.F. Genetic And Structural Homology Of Stem Cell Factor and Macrophage Colony-Stimulating factor. Cell (1991) 65:9-10 (Exhibit 9).
Besmer, P. A New Acute Transforming Feline Retrovirus and Relationship of its Oncogene v-kit with the Protein Kinase Gene Family. Nature (1986) 320:415-421 (Exhibit 10).
Bischoff, S.C., and Dahinden, C.A. C-Kit Ligand: A Unique Potentiator Of Mediator Release by Human Lung Mast Cells. J. Exp. Med. (1992) 175:237-244 (Exhibit 11).
Chabot, B. The Proto-Oncogene C-Kit Encoding A Transmembrane Tyrosine Kinase Receptor Maps To The Mouse W Locus. Nature (1988) 335:88-89 (Exhibit 12).
Copeland, N.G. Mast Cell Growth Factor Maps near the steel Locus On Mouse Chromosome 10 and Is Deleted In A Number OffSteel Alleles. Cell (1990) 63:175-183 (Exhibit 13).
Flanagan, J.G. and Leder, P. The Kit-Ligand: A Cell Surface Molecule Altered In Steel Mutant Fibroblasts. Cell (1990) 63:185-194 (Exhibit 14).
Flanagen, J.G., et al. Transmembrane Form Of The Kit Ligand Growth Factor Is Determined By Alternative Splicing And Is Missing in the SId Mutant. Cell (1991) 64:1025-1035 (Exhibit 15).
Geissler, E.N., et al. The Dominant-White Spotting (W) Locus of the Mouse Encodes the C-Kit Proto-Oncogene. Cell (1988) 55:185-192 (Exhibit 16).
Huang, E., et al. The Hematopoietic Growth Factor KL Is Encoded by the SI Locus and is the Ligand of the C-Kit Receptor, the Gene Product of the W. Locus. Cell (1990) 63:225-233 (Exhibit 17).
Karhumaki, E. An Improved Enrichment Method For Functionally Competent, Highly Purified Peripheral Blood Dendritic Cells And its Application To HIV-Infected Blood Samples. Clin. Exp. Immunol. (1993) (Exhibit 18).
Martin, F.H., et al. Primary Structure and Functional Expression of rat and human Stem Cell Factor DNAs. Cell (1990)63:203-211(Exhibit 19).
Majumder, S., et al. C-Kit Protein, a Transmembrane Kinase: Identification In Tissues and Characterization. Molecular and Cellular Biology. (1988) 8:4896-4903 (Exhibit 20).
Cell Factor On Murine Bone Marrow Cells In Vitro: effects of Combination With Colony-Stimulating Factors. Proc. Natl. Acad. Sci. USA 886239-6243 (Exhibit 21).
Moore, M.A.S., Clinical Implications of Positive and Negative Hematopoietic Stem Cell Regulators. The Journal of The American Society of Hematology (1991) 78:1-19 (Exhibit 22).
Moore, M.A.S., and Warren, D.J. Synergy of Interleukin 1 and Granulocyte Colony-Stimulating Factor: In Vivo stimulation of Stem Cell Recovery and Hematopoietic Regeneration Following 5-Fluorouracil Treatment of Mice. Proc. Natl. Acad. Sci. USA (1987) 84:7134-7138 (Exhibit 23).
Muench, M.O., et al. Interactions Among Colony-Stimulating Factors, IL-1b, IL-6, and Kit-Ligand In The Regulation Of Primitive,Murine Hematopoietic Cells. Exp. Hematol. (1992) 20:339-349 (Exhibit 24).
Nocka, K.H., et al. Candidate Ligand For C-Kit: Purification of a Fibroblast-Derived Mast Cell Growth Factor. Experimental Hematology (1990) 18:253 (Exhibit 25).
Nocka, K, et al. Expression of C-Kit Gene Products In Known Cellular Targets Of W Mutations In Normal And W Mutant Mice-Evidence For An Impaired C-Kit Kinase In Mutant Mice. Genes & Development (1989) 3:816-826 (Exhibit 26).
Nocka, K, et al. Molecular Bases Of Dominant Negative and Loss Of Function Mutations At the Murine C-Kit/White Spotting Locus: W37, WV, W41, and W. The EMBO Journal (1990) 9:1805-1813 (Exhibit 27).
Nocka, K, et al. Candidate Ligand For The C-Kit Transmembrane Kinase Receptor: KL, A Fibroblast Derived Growth Factor Stimulates Mast Cells And Erythroid Progenitors. The EMBO Journal (1990) 9:3287-3294 (Exhibit 28).
Orr-Urtreger, A. et al. Development Expression of C-Kit, A Proto-Oncogene Encoded By The W Locus. Development (1990) 109:911-923 (Exhibit 29).
Qiu F., et al. Primary Structure C-Kit: Relationship With The CSF-1/PDGF Receptor Kinase Family-Oncogene Activation Of V-Kit Involves Deletion Of Extracellular Domain and C Terminus. IRL Press Limited, Oxford, England. (Exhibit 30).
Reith, A.D., et al. W Mutant Mice With Mild Or Severe Developmental Defects Contain Distinct Point Mutations In the Kinase Domain Of the C-Kit Receptor. Genes & Development (1990) 4:390-400 (Exhibit 31).
Tan, J.C., et al. The Dominant W42 Spotting Phenotype Results From A Missense Mutation In The C-Kit Receptor Kinase. Science Reports (1990) 209-212. (Exhibit 32).
Tazi, A., et al. Evidence That Granulocyte Macrophage-Colony Stimulating Factor Regulates The Distribution And Differentiated State Of Dendritic Cells/Langerhans Cells In Human Lung And Lung Cancers. (1993) 91:566-576 (Exhibit 33).
Thomas, R., et al. Isolation and Characterization of Human Peripheral Blood Dendritic Cells. The Journal of Immunology (1993) 150:821-834 (Exhibit 34).
Williams, D.E., et al. Identification of a Ligand for the C-Kit Proto Oncogene. Cell (1990) 63:167-174 (Exhibit 35).
Yarden, Y., et al, Human Proto-Oncogene C-Kit: A New Cell Surface Recept Tyrosine Kinase For An Unidentified Ligand. The EMBO Journal (1987) 6:3341-3351 (Exhibit 36).
Zsebo, K.M., et al. Identification, Purification, and Biological Characterization of Hematopoietic Stem Cell Factor From Buffalo Rat Liver-Conditioned Medium. Cell (1990) 63:195-201 (Exhibit 37).
Zsebo, K.M., et al. Stem Cell Factor Is Encoded At The SI Locuse of the Mouse and is the Ligand for the C-Kit Tyrosine Kinase Receptor. Cell (1990) 63:213-224 (Exhibit 38).
Metcalf, D. et al. PNAS 88:6239-6243 (1991).
Mayani, H. et al. Experimental Hematology 23:422-427 (1995).
Rusten, L.S. et al. J. Clin. Invest. 94:165-172 (1994).
Besmer Peter
Buck Jochen
Moore Malcolm A. S.
Nocka Karl
Carlson K. Cochrane
Jagannathan Vasu S.
Sloan-Kettering Institute for Cancer Research
White John P.
LandOfFree
Composition of c-kit ligand, GM-CSF, and TNF-.alpha. and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition of c-kit ligand, GM-CSF, and TNF-.alpha. and method , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition of c-kit ligand, GM-CSF, and TNF-.alpha. and method will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-863426