Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Egg enclosed in shell or a part thereof
Reexamination Certificate
2002-10-07
2004-04-13
Tate, Christopher R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Egg enclosed in shell or a part thereof
C424S195170, C424S725000, C426S231000
Reexamination Certificate
active
06720010
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to compositions having antihepatitic activity containing components derived from natural substances, and more particularly to compositions having antihepatitic activity containing dry product of defatted whole egg of eggs of a fowl bred by feeding a feed containing dry products of certain plants.
BACKGROUND OF THE INVENTION
In Japan, chronic hepatitis afflicts a huge number of persons, a majority of which is occupied by hepatitis B virus (HBV) and hepatitis C virus (HCV) carriers. Chronic hepatitis is a disease very difficult to cure. It is highly possible that after a long progress it proceeds into cirrhosis and further into hepatoma and there is no decisive specific for curing it. Methods for curing the disease currently focus on interferon (IFN) treatment contemplated to control or disinfect viruses.
However, IFN treatment has its limit and there is no other decisive therapy, so that the therapy of chronic hepatitis takes a long period of time anyhow. Accordingly, an auxiliary treatment in which glycyrrhizin formulations or Chinese galenicals such as malgranda bu-supo is used in combination has been used widely as a means for inhibiting the progress of the disease and improving the liver function injury. In particular, malgranda bu-supo, one of Chinese galenicals, causes side effects to a lesser extent than other drugs do and is relatively high in therapeutic index in respect of inhibition of inflammation. Therefore, it has come to attention.
Recently, however, the very malgranda bu-supo has come to fail to give satisfaction since its use in combination with an IFN formulation, which is the first selected drug for chronic hepatitis C, has frequently caused a side effect called interstitial pneumonia and such combined use has become a contradiction.
In any rate, under the present circumstances where no potent radical cure other than IFN treatment is present, there is little alternative therapy that supplements it. Thus, the patients suffering from chronic hepatitis desire the appearance of a novel drug for the therapy of hepatitis, which can be used daily and continuously for a long period of time with peace in mind.
Under the circumstances, challenges have been made on utilization of Chinese galenicals other than malgranda bu-supo or compositions derived from other natural substances as antihepatitic drugs. Actually, many such challenges have been described or reported in many patent publications, academic literature, and the like. There remains an ample possibility that further searches on natural substances will result in finding effective drug components.
In the case of intractable diseases such as chronic hepatitis whose therapy takes a long period of time, it is needless to say that the problems of side effects of a drug to be used and of drug tolerance in that the affected area of a patient resists the drug will become serious hindrances to the therapy.
However, it is considered that the conventional methods in which a drug component alone is isolated and purified or semi-synthesized from a particular natural substance as a therapeutic drug cannot solve the above-mentioned problems. So far as the organism (or living body) recognizes the drug as a foreign matter containing a cytotoxic factor, the problems of side effects and drug tolerance cannot be avoided to occur. Furthermore, other problems on drugs derived from natural substances include one that in many cases the component found with difficulty is poor as a resource, so that its industrial application is impossible.
SUMMARY OF THE INVENTION
Therefore, an object of the present invention is to conduct a search for natural drugs and their formulae derived from natural substances that hardly cause side effects and drug tolerance, based on quite a new idea having departed from conventional drugs such as Chinese galenicals, Chinese medicine formulae, etc. and to develop a composition that has an antihepatitic activity.
Accordingly, the inventors of the present invention have made extensive studies with a view to solving the above-described problems and as a result they have found that a dry product of defatted whole egg (hereinafter referred to as “defatted whole egg dry product”) of eggs produced by a fowl bred by feeding a feed to which a dry product of
Angelica keiskei
(“Ashitaba”, in Japanese) (hereinafter referred to as “
Angelica keiskei
dry product”) and optionally a dry product of
Theaceae Camellia
(“Tsubaki”, in Japanese) (hereinafter referred to as “
Theaceae Camellia
dry product”) has antihepatitic activity. Also, the inventors of the present invention have found that a composition containing in addition to the above-mentioned defatted whole egg dry product, the
Angelica keiskei
dry product and optionally the
Theaceae Camellia
dry product has antihepatitic activity.
That is, the inventors of the present invention have found that the composition containing the above-mentioned defatted whole egg dry product has antihepatitic activity, i.e., an activity of preventing an increase in serum transaminase level associated with liver diseases and also that the composition containing the defatted whole egg dry product, the
Angelica keiskei
dry product and optionally the
Theaceae Camellia
dry product has excellent antihepatitic activity.
The present invention has been accomplished based on these findings.
According to a first aspect of the present invention, the present invention relates to a composition having an antihepatitic activity, characterized by comprising a dry product of defatted whole egg of eggs of a fowl bred by feeding a feed having blended therein an additive comprising a dry product of
Angelica keiskei
, a dry product of brown algae, and optionally a dry product of
Theaceae Camellia.
According to a second aspect of the present invention, the present invention relates to a composition according to the first aspect of the invention, wherein the fowl is a member selected from the group consisting of hens, ducks and quails.
According to a third aspect of the present invention, the present invention relates to a composition having antihepatitic activity, characterized by comprising a dry product of defatted whole egg of the first aspect of the invention and a dry product of
Angelica keiskei.
According to a fourth aspect of the present invention, the present invention relates to a composition having antihepatitic activity, characterized by comprising a dry product of defatted whole egg of the first aspect of the invention, a dry product of
Angelica keiskei
and a dry product of
Theaceae Camellia.
According to the present invention, novel natural drugs derived from natural substances departing from conventional drugs Chinese galenicals, Chinese medicine formulae, etc. are provided. That is, compositions that contain components derived from natural substances as effective components and have antihepatitic activity are provided. In particular, the compositions of the present invention are excellent in specific antihepatitic effect to trouble in liver induced by drugs.
In addition, the compositions of the present invention are extremely weak in toxicity so that it is expected that they can be utilized not only in the therapy of hepatitis, etc. as drugs but also in preventing the above-mentioned diseases by adding them to various foods and taking them daily.
DETAILED DESCRIPTION OF THE INVENTION
As described above, the present invention relates to compositions having antihepatitic activity derived from familiar products that have never been used conventionally as raw materials, such as
Angelica keiskei
and
Theaceae Camellia
, which are natural substances, as well as a dry product of whole egg defatted from specific eggs produced by utilizing such natural substances as feeds.
Although it is unclear as to what compound contained in the components constituting the composition of the present invention is the main body that exhibits pharmacological activity, it is believed that a plurality of compounds contained therein act in combination w
Iijima Aizo
Iijima Hideshi
Iijima Corporation
Tate Christopher R.
Winston Randall
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