Composition having anti-endotoxic activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 53, 536 11, 536125, 536127, 127 462, 127 53, A61K 3170, C07H 106, C13K 500

Patent

active

051283239

ABSTRACT:
The invention relates to pharmaceutical compositions having antiendotoxic activity, comprising as the active component a fraction which can be isolated from lactulase syrup by means of absorption at a sulphonated polystyrene cation resin in the Ca.sup.2+ - form and elution with a suitable solvent. The lactulose syrup can be obtained by basic isomerization of lactose at elevated temperature, optionally in the presence of sodiumsulphite.

REFERENCES:
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patent: 3816174 (1974-06-01), Nagasawa et al.
patent: 4067748 (1978-01-01), Rowe
patent: 4536221 (1985-08-01), Carobbi et al.
patent: 4555271 (1985-11-01), Carobbi et al.
patent: 4565582 (1986-01-01), Filippini et al.
patent: 4931554 (1990-06-01), Bijl et al.
patent: 4957564 (1990-09-01), Carobbi et al.
patent: 5003061 (1991-03-01), Carobbi et al.
Van Vugt et al; Chemical Abstracts 99:17787d (1983).
Liehr et al; Hepato.-Gastroenterology 27:356-360 (1980).
Van Vugt et al; Hepatology 3(2):236-240 (1983).
de Groot et al; Hepato-Gastroenterology 30:240-242 (1983).
Ditter et al; Gastroenterology 84:1547-1552 (1983).
Lind et al; Anesthesiology 61:544-550 (1984).

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