Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Ophthalmic preparation
Patent
1991-04-23
1991-12-24
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Topical body preparation containing solid synthetic organic...
Ophthalmic preparation
424427, 424428, 514499, 514188, A61K 3179
Patent
active
050751050
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to medicine and more specifically a composition for treatment of progressive myopia.
PRIOR ART
At present a complex of therapeutic measures applied against progressive myopia involves various methods aimed at reinforcing the posterior pole of the eyeball. Alongside with conventional surgical methods search for new methods and means for operationless effects upon the sclera aimed at directional correction of the myopic process proves to be the currently central problem.
One state-of-the-art medicinal agent for treatment of progressive myopia (SU, A, 1,156,680; Ophthalmological Herald, 1985, Moscow, Meditsina Publishers, vol. 101, No. 2, pp. 31-36) is known to appear as a foaming gel-like composition, incorporating a dry mixture of polyvinylpyrrolidone, acrylamide-hydrazide, and ethylacrylate, and a dissolving mixture, consisting of ferrous chloride, cupric citrate, boric acid, hydrochloric acid, and distilled water, as well as an activator, i.e., a 3-percent hydrogen peroxide that promotes foaming of the composition. The aforesaid composition is injected under the Tenon's capsule to establish an elastic foamed gel on the scleral surface, which while being gradually replaced by the freshly formed connective tissue, adds to the strength characteristics of the sclera. However, the studies performed have demonstrated that formation of a connective capsule on the scleral surface and a process of its reinforcing occur at a relative slow rate, which is accounted for by a definite formulation of said composition, whose active components stimulate the synthesis of collagen and provide for its structural stability.
DISCLOSURE OF THE INVENTION
It is an object of the present invention to provide a composition that would be capable of accelerating the formation of a connective capsule and adding to the elastic-strength characteristics of the sclera due to qualitative and quantitative changes of starting components thereof.
Said object is accomplished due to the fact proposed herein is a composition for treatment of progressive myopia, incorporating a mixture of polyvinylpyrrolidone, acrylamide-hydrazide and ethylacrylate, an aqueous solution of an iron compound, cupric citrate, boric and hydrochloric acids, and hydrogen peroxide, said composition comprising also dichlorodi-[2-methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine] of copper (II) with the following mass-percent ratio of the starting components:
______________________________________ mixture of polyvinylpyrrolidone, acrylamide-
18.8 to 29.5
hydrazide and ethylacrylate (taken in equal pro-
portions)
aqueous solution, containing the following
69.5 to 80.1
ingredients, mg/l:
hydrochloric acid
940.0
boric acid 4.12
ferrous oxide (II)
115.0
cupric citrate
16.0
3-percent aqueous hydrogen peroxide
0.79 to 0.89
dichlorodi-[2-methyl-3-hydroxy-4,5-di-
0.11 to 0.31.
(hydroxymethyl)-pyridine] of copper (II)
______________________________________
The proposed composition promotes formation of the fresh connecting tissue, this being due intensified processes of collagen biosynthesis, as well as contributes to increases elastic-strength parameters of the scleral tissue .
PREFERRED EMBODIMENT OF THE INVENTION
The proposed composition resulting from intermixing of the mixture of polymers, the aforesaid aqueous solution, and the copper compound, should appear as a homogeneous liquid gel free from any alien inclusions, inhomogeneous components, or clumps, which is to be assessed visually.
Once having been doped with an activator (i.e., a 3-percent aqueous solution of hydrogen peroxide) the composition turns into a soft elastic foamed gel having a density (volume weight) of from 0.46 to 0.57 g/cm.sup.3.
The mixture of polyvinylpyrrolidone, acrylamidehydrazide, and ethylacrylate (taken in equal proportions) that makes part of the proposed composition in an amount of 69.5 to 80.1 mass percent, proves to be a principal basic structure of the foamlike composition. The aforespecified amounts
REFERENCES:
patent: 4470965 (1984-09-01), Wolf et al.
patent: 4525346 (1985-06-01), Stark
patent: 4615882 (1986-10-01), Stockel
Andreeva Ljudmila D.
Avetisov Eduard S.
Boltaeva Zulfia K.
Davydov Anatoly B.
Dolgopyatova Antonina A.
Page Thurman K.
Piccone Louis A.
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