Composition for treating psoriasis vulgaris and a method for its

Details Composition for treating psoriasis vulgaris and a method for its Composition for treating psoriasis vulgaris and a method for its

1986-09-17

1988-04-26

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

514170, 514863, A61K 3156, A61K 3748

Patent

active

047403721

ABSTRACT:
A composition for the treatment of psoriasis vulgaris, and a method for its preparation are described. The compound is made from the following ingredients: 6.alpha.,9.alpha.-difluoro-11.beta., 17.alpha.-dihidroxy-16.alpha.-methyl-21 trimethyl-acetoxy-1,4-pregnadiene-3,20 dione; (+)-17,21-dipropionyloxy-16.beta.-methyl-9.alpha.-fluoro-prednisolone; salicylic acid; tetracycline chloride; gentamycin sulfate; neomycin sulfate; trypsin; chymotrypsin; and bismuth. A method for the preparations of this composition is also disclosed. In this method, 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.-dihidroxy-16.alpha.-methyl-2 1-trimethyl-acetoxy-1,4-pregnadiene-3,20 dione and (+)-17,21-dipropionyloxy-16.beta.-methyl-9.alpha.-fluoroprednisolone are first mixed together under intensive agitation. Salicyclic acid, tetracycline chloride, gentamycin sulfate and neomycin sulfate are then added. Next, trypsin, chymotrypsin and bismuth are added. Finally, the preparation is mixed into a neutral cream, ointment, etc., at which time it is ready for use. This unique composition of ingredients acting together achieves excellant results in the treatment psoriasis vulgaris.

REFERENCES:
patent: 3787454 (1974-01-01), Kerb et al.
patent: 3934013 (1976-01-01), Poulsen

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