Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1981-01-13
1983-09-20
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
424283, A61K 3135
Patent
active
044055986
ABSTRACT:
There is described a method of treatment of asthma which comprises administration to an asthmatic patient of an effective amount of an inhalation composition consisting essentially of a dispersion or suspension of from 0.2 to 2.0% disodium cromoglycate of mass median diameter 0.01 to 10 microns, from 0.15 to 2.0% by weight of a sorbitan or sorbitol ester surfactant and a propellant mixture comprising dichlorodifluoromethane and 1,2-dichloro-1,1,2,2-tetrafluoroethane, the ratio of dichlorodifluoromethane to 1,2-dichloro-1,1,2,2-tetrafluoroethane, in said mixture being in the range from 2:1 to 1:1 by weight, the disodium cromoglycate used in the formulation containing from 0.05 to 1% w/w of water and the total formulation containing less than 0.1% w/w of water and having a vapor pressure in the range 35 to 70 pounds per square inch gauge.
There is also described disodium cromoglycate having a mass median diameter of less than 20 microns, more preferably in the range 0.01 to 10 microns, and most preferably at least 50% by weight of the particles having a diameter of 2 to 5 microns and containing less than 1% by weight of water.
REFERENCES:
patent: 3282791 (1966-11-01), Macek
patent: 3560607 (1971-02-01), Hartley
patent: 3897779 (1975-08-01), Hansen
Physicians Desk Reference, (PDR), 30th Ed., pp. 805-806.
Merck Index-9th Ed., 1976.
Remington's Pharmaceutical Chemistry, 13th Ed., pp. 659-662.
Fisons Limited
Schenkman Leonard
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