Composition for transdermal delivery of drugs

Details Composition for transdermal delivery of drugs Composition for transdermal delivery of drugs

1998-07-07

2001-07-03

Williamson, Michael C. (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

C424S448000, C602S041000, C604S020000, C604S890100

Reexamination Certificate

active

06254883

ABSTRACT:

This invention relates to a novel composition for controlled release of a drug in transdermal administration.
BACKGROUND OF THE INVENTION
The publications and other materials used herein to illuminate the background of the invention, and in particular, cases to provide additional details respecting the practice, are incorporated by reference.
Transdermal delivery is a feasible alternative route of drug administration for many drugs. Drugs whose daily dose is 20-30 mg or less, are potential candidates for transdermal drug delivery (Guy and Hadgraft 1987, Guy and Hadgraft 1989).
Transdermal administration of therapeutically active agents is usually accomplished by incorporating the drug into a transdermal delivery device which is able to control the delivery rate of the drug. According to one alternative the transdermal device comprises a backing layer, an adhesive layer and a matrix layer preferably made of a polymer material in which the drug is dispersed. The rate of which the drug is released from the device is here controlled by the polymer matrix. Another kind of transdermal device is the reservoir system comprising a) a drug impermeable backing layer, b) an adhesive layer, c) a drug permeable membrane sealed to one side of the backing layer as to define a drug reservoir compartment there between, and d) a drug or composition thereof within said drug reservoir. In this case the drug in the reservoir is usually in liquid or gel form. The drug permeable membrane controls the rate at which the drug is delivered to the skin.
U.S. Pat. No. 4,692,462 describes a composition and method for controlled transdermal delivery based on the use of a ion exchange resin loaded with the drug to be administered. This drug-loaded ion exchange resin is, together with a salt that is able to release the drug from the ion exchange resin, mixed with a gel-forming vehicle and incorporated in a device having a cavity, an adhesive layer and a backing layer.
SUMMARY OF THE INVENTION
The object of this invention is to provide a transdermal delivery composition which combine the features of controlled drug release and simple device construction.
The invention thus concerns a pharmaceutical composition for the controlled transdermal delivery of a drug comprising a combination of a drug and a ion exchanger group grafted to a carrier, and a pharmaceutically acceptable salt that is able to control the release of the drug from the ion exchanger. According to the invention the carrier is a textile fiber.


REFERENCES:
patent: 1967927 (1934-07-01), Deutsch
patent: 4032452 (1977-06-01), Davis
patent: 4585652 (1986-04-01), Miller et al.
patent: 4731049 (1988-03-01), Parsi
patent: 5098417 (1992-03-01), Yamazaki et al.
patent: 5162042 (1992-11-01), Gyory et al.
patent: 5603955 (1997-02-01), Gehrke et al.
patent: 5894021 (1999-04-01), Okabe et al.
patent: 0 195 643 A3 (1986-09-01), None
patent: 925030 (1992-11-01), None
patent: 95774 (1995-12-01), None
patent: WO 90/03825 (1990-04-01), None
patent: WO 92/15365 (1992-09-01), None
patent: WO 94/08572 (1994-04-01), None
patent: WO 96/10441 (1996-04-01), None
Chien et al., “Development of Transdermal Controlled Release Drug Delivery Systems: An Overview,” 1Transdermal Delivery of Drugs81-100 (1987).
Baker et al., “Materials Selection for Transdermal Delivery Systems,”Transdermal Drug Delivery, Developmental Issues and Research Initiatives293-311 (1989).
Sathyan et al., “Transdermal delivery of tacrine,” 114Int. J. Pharm75-83 (1995) (Abstract only).*
Moriearty, “Transdermal Delivery of Cholinesterase Inhibitors,” 4CNS Drugs323-334 (1995).

Affiliated with

Also associated with

Rating

Composition for transdermal delivery of drugs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Composition for transdermal delivery of drugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition for transdermal delivery of drugs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2566683