Composition for transdermal and/or transmucosal...

Details Composition for transdermal and/or transmucosal... Composition for transdermal and/or transmucosal...

2008-07-29

2008-07-29

Richter, Johann (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

C424S436000, C424S449000, C424S464000

Reexamination Certificate

active

11634005

ABSTRACT:
A pharmaceutical composition in the form of a solution, cream, lotion, spray, ointment, gel, aerosol, tablet, suppository or patch device for transdermal or transmucosal administration of alprazolam to a subject, which includes as a permeation enhancing mixture a fatty component in an amount of 0.1% to 20% by weight which is one of (a) a saturated fatty alcohol of formula CH3—(CH2)n—CH2OH, a saturated fatty acid of formula CH3—(CH2)n—CH2COOH, (b) an unsaturated fatty alcohol of formula CH3(CnH2(n−1))—OH, or (c) a fatty acid of formula CH3(CnH2(n−1))—COOH, wherein n is an integer of between 8 and 22; and a vehicle that includes a C1-C4alkanol, a polyalcohol, and water.

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