Composition for tissues to sustain viability and biological func

Details Composition for tissues to sustain viability and biological func Composition for tissues to sustain viability and biological func

1994-03-28

1997-08-05

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 514546, 514912, A61K 3122, A61K 3800

Patent

active

056542666

ABSTRACT:
A composition composing ketone bodies and/or precursors thereof and an aqueous phosphate-buffered balanced salt solution with citrate, HPO.sub.4.sup.-2 and Ca.sup.2+ in a defined concentration ratio, and methods, including a mechanism and an associated set of protocols, to make the solution without causing autoclave-elicited caramelization and precipitation in the manufacturing process are disclosed. The disclosed composition is particularly useful as a rich energy source for isolated tissue and for peripheral tissues under surgery with concurrent suppression of lactic acid formation and accumulation in the cells. It may be used in ocular surgery and surgeries in general, although other uses, for example, topical application and storage and rinsing of donor tissues prior to transplantation are also contemplated.

REFERENCES:
patent: 5298487 (1994-03-01), Chen et al.

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