Composition for the treatment and prevention of ischemic events

Details Composition for the treatment and prevention of ischemic events Composition for the treatment and prevention of ischemic events

2006-04-18

2006-04-18

Padmanabhan, Sreeni (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S451000, C424S457000, C424S464000, C424S468000, C424S490000, C514S960000, C514S964000

Reexamination Certificate

active

07029701

ABSTRACT:
The invention relates to pharmaceutical compositions comprising omeprazole and aspirin wherein the combination is useful for the treatment and prevention of cardiovascular events including heart attacks and platelet aggregation leading to a potential cardiac event. A variety of drug delivery systems may be utilized to deliver the combination of active ingredients. The preferred delivery system utilizes a tablet or capsule containing an inert sugar core particle that is coated with subparticles of a coated omeprazole wherein the coating contains omeprazole, a binder, a surface active agent and a basifying agent along with a filler. The aspirin may be combined with this formulation to coat the sugar sphere or it may be part of a separate coating composition that forms a multilayer system that is ultimately coated with an enteric coating and then formed into the tablet or capsule by conventional means.

REFERENCES:
patent: 6365184 (2002-04-01), Depui et al.
patent: 6605303 (2003-08-01), Karehill et al.
patent: 6610323 (2003-08-01), Lundberg et al.

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