Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-06-07
1998-02-10
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
264 46, 424460, 424462, 424491, 427 221, 514 8, 514963, 514965, A61K 950, A61K 952
Patent
active
057166447
ABSTRACT:
A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, aggregation-stabilized EPO, wherein said particles are dispersed within the biocompatible polymer.
The method of the invention for producing a composition for the sustained release of biologically active EPO, includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, aggregation-stabilized EPO in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of said EPO particles.
The method for using a composition of the invention is a method for providing a therapeutically effective blood level of biologically active, non-aggregated erythropoietin in a subject for a sustained period. In this method, a subject is administered an effective dose of the sustained release composition of the present invention.
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Bernstein Howard
Brickner Avram
Burke Paul A.
Zale Stephen E.
Alkermes, Inc.
Lovering Richard D.
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