Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-06-07
1997-08-05
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424423, 424426, 424489, 424499, 424500, 424501, 514 21, 530399, 530839, A61F 202, A61K 914, A61K 950, A61K 3824
Patent
active
056540108
ABSTRACT:
A composition, and methods of forming and using said composition, for the sustained release of biologically active, stabilized human growth hormone (hGH). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, stabilized hGH, wherein said particles are dispersed within the biocompatible polymer. The method of the invention for producing a composition for the sustained release of biologically active hGH, includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, stabilized hGH in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of said hGH particles. The method for using a composition of the invention is a method for providing a therapeutically effective blood level of biologically active, non-aggregated hGH in a subject for a sustained period. In this method, a subject is administered an effective dose of the sustained release composition of the present invention. The method of using the sustained release composition of the present invention comprises providing a therapeutically effective blood level of biologically active, non-aggregated human growth hormone in a subject for a sustained period by administering to the subject a dose of said sustained release composition.
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Auer Henry
Bernstein Howard
Ganmukhi Medha M.
Johnson OluFunmi Lily
Khan M. Amin
Alkermes, Inc.
Azpuru Carlos
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