Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-06-07
1997-09-16
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424426, 424502, 5147723, 42840221, 264 46, A61K 950, A61K 4732, A61F 202, B32B 516
Patent
active
056678088
ABSTRACT:
The method of using the sustained release composition of the present invention comprises providing a therapeutically effective blood level of biologically active, non-aggregated human growth hormone in a subject for a sustained period by administering to the subject a dose of said sustained release composition.
REFERENCES:
patent: 4675189 (1987-06-01), Kent et al.
patent: 4767628 (1988-08-01), Hutchinson
patent: 4853218 (1989-08-01), Yim et al.
patent: 4891225 (1990-01-01), Langer et al.
patent: 4897268 (1990-01-01), Tice et al.
patent: 4906474 (1990-03-01), Langer et al.
patent: 4962091 (1990-10-01), Eppstein et al.
patent: 4981696 (1991-01-01), Loomis et al.
patent: 4985404 (1991-01-01), Mitchell
patent: 5019400 (1991-05-01), Gombotz et al.
patent: 5122367 (1992-06-01), Ron et al.
patent: 5126147 (1992-06-01), Silvestri et al.
patent: 5176907 (1993-01-01), Leong
patent: 5192741 (1993-03-01), Orsolini et al.
Cunningham, B. C., et al, "Dimerization of Human Growth Hormone by Zinc," Science, 253: 545-548 (Aug. 2, 1991).
Costantino, H. R., et al., "Solid-Phase Aggregation of Proteins under Pharmaceutically Relevant Conditions, " Journal of Pharmaceutical Sciences, 83(12): 1662-1669 (1994).
Costantino, H. R., et al., "Moisture-Induced Aggregation of Lyophilized Insulin," Pharmaceutical Researd,11(1): 21-29 (1994).
Costantino, H. R., et al., "Aggregation of a Lyophilized Pharmaceutical Protein, Recombinant Human Albumin: Effect of Moisture and Stabilization by Excipients," Biotechnology,13: 493-496 (1995).
Cleland, J. L., et al., "One Month Continuous Release Recombinant Human Growth Hormone-PLGA Formulations," Proceed. Intern. Symp. Control. Rel. Bioact. Mater.,22: 149-150 (1995).
Cleland, J. L., et al, "Characterization of Recombinant Human Growth Hormone-PLGA Formulations in Animals," Proceed. Intern. Symp. Control. Rel Bioact. Mater.,22: 143-144 (1995).
Auer Henry
Bernstein Howard
Ganmukhi Medha M.
Johnson OluFunmi Lily
Khan M. Amin
Alkermes, Inc.
Azpuru Carlos A.
LandOfFree
Composition for sustained release of human growth hormone does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition for sustained release of human growth hormone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition for sustained release of human growth hormone will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-216374