Composition for sustained delivery of hydrophobic drugs and...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

Reexamination Certificate

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Details

C424S400000, C424S422000, C424S423000, C514S772300, C514S772100

Reexamination Certificate

active

07153520

ABSTRACT:
A composition for the sustained delivery of a drug comprising an amphiphilic diblock copolymer; a poorly water-soluble drug; a biodegradable polymer; and liquid poly(ethylene glycol) or functional derivatives thereof and a process for preparing the composition are disclosed. When administered into a particular body site, the composition forms an implant containing the drug and drug containing polymeric micelles, which are slowly released from the implant to maintain a constant drug concentration for an extended period of time.

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So Yeon Kim, et al,Methoxy Poly(ethylene glycol)and ε-Caprolactone Amphiphilic Block Copolymeric Micelle Containing Indomethacin. II. Micelle formation and drug release behaviours, J. Cont. Rel. 51 (1998) 13-22.
E.Piskin, et al,Novel PDLLA/Peg Copolymer Micelles as Drug Carriers, J. of Biomater. Sci. Polymer Edn. 7(4) (1995) 359-373.

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