Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-08-23
2011-08-23
McGarry, Sean (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S024300, C536S024330
Reexamination Certificate
active
08003781
ABSTRACT:
Disclosed is a means for reducing the expression amount of a FUT8 gene, reducing the expression amount of a FUT8 protein, and/or reducing the expression amount of a product produced by the action of FUT8.
REFERENCES:
patent: 2004/0132140 (2004-07-01), Satoh et al.
patent: 2006/0223147 (2006-10-01), Nishiya et al.
patent: 2007/0134759 (2007-06-01), Nishiya et al.
patent: 2005/058111 (2005-03-01), None
patent: 2005224240 (2005-08-01), None
Ryther et al. siRNA therapeutics: big potential from small RNAs. Gene Therapy, 2005 vol. 12, pp. 5-11.
Ito et al. (Cancer Letters, 2003, vol. 200:167-172).
K. Noda, et al., “Relationship between elevated FX expression and increased production of GDP-L-Fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines”, Cancer Rersearch, Oct. 1, 2003, p. 6282-6289, vol. 63.
S. Yanagidani, et al., “Purification and cDNA cloning of GDP-L-Fuc: N-Acetyl-β-D-Glucosaminide: {acute over (α)}1-6 Fucosyltransferase ({acute over (α)}1-6 FucT) from human gastric cancer MKN45 cells”, J. Biochem, 1997, p. 626-632, vol. 121, No. 3.
H. Hayashi, et al., “Molecular cloning of mouse Alpha-1, 6-Fucosyltransferase and expression of its mRNA in the developing cerebrum”, DNA Sequence, 2000, p. 91-96, vol. 11(1-2), Overseas Publishers Association.
N. Caplen, et al., “Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems”, Proc. Natl. Acid. Sci., Aug. 14, 2001, p. 9742-9747, vol. 98, No. 17.
“Letters to nature”, Nature, May 24, 2001, p. 494-498, vol. 411, Macmillan Magazines Ltd.
A. Kondo, et al., “A basic investigation on suppression of the proliferation of hepatic cancer cells through suppression of glycosylrtransferase”, Acta Hepatologica Japonica, 2005, p. A144(O-138), vol. No. 46 suppl. 1.
N. Taniguchi, et al., “Functional glyconomics and evidence for gain- and loss-of-functions of target proteins for glycosyltransferasees involved in N-glycan biosynthesis: their pivotal roles in growth and development, cancer metastasis and antibody therapy against cancer”, Poc. Japan Acad., Ser. B, 2004, p. 82-91, vol. 80.
K. Mori, et al., “Engineering chinese hamster ovary cells to maximze effector function of produced antibodies using FUT8 siRNA”, Biotechnology and Bioengineering, Dec. 30, 2004, p. 901-908, vol. 88, No. 7, Wiley Periodicals.
Kato Ikunoshin
Kondo Akihiro
Koyama Nobuto
Li Wenzhe
Nakagawa Takatoshi
Browdy and Neimark PLLC
Gibbs Terra Cotta
McGarry Sean
Osaka University
Takara Bio Inc.
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