Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-08-22
1995-12-26
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514220, 514250, 514253, 514322, 514383, A61K 3155, A61K 31495, A61K 3150, A61K 31445, A61K 3141
Patent
active
054788234
ABSTRACT:
An agent for suppressing infiltration of eosinophils comprising as an effective ingredient a tricyclic triazolo derivative, which strongly suppresses infiltration of eosinophils into inflammatory regions, of the formula (I): ##STR1## wherein R.sup.1 represents hydrogen, lower alkyl, C.sub.3 -C.sub.5 cycloalkyl or substituted or non-substituted aryl; R.sup.2 and R.sup.3 independently represent hydrogen, lower alkyl, lower alkoxy or halogen; W represents C.dbd.O or CR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 independently represent hydrogen or lower alkyl; A represents C.sub.1 -C.sub.5 straight or branched saturated or unsaturated alkylene with the proviso that it may contain one or more hetero atoms; 1 represents 0 to 2, n represents 1 to 3, -- represents single bond or double bond; Y represents N or C; Z represents C(B)Ar.sup.1 Ar.sup.2 wherein B represents hydrogen, hydroxy or methoxy, Ar.sup.1 and Ar.sup.2 independently represent hydrogen or substituted or non-substituted aryl, CAr.sup.1 Ar.sup.2 wherein Ar.sup.1 and Ar.sup.2 represent the same meanings as mentioned above, O--CHAr.sup.1 Ar.sup.2 wherein Ar.sup.1 and Ar.sup.2 represent the same meanings as mentioned above or a condensed aromatic ring or a pharmaceutically acceptable salt thereof.
REFERENCES:
Drug Des Deliv., vol. 5, No. 1, 1989, H. O. Heuer, "Hetrazepinoic antagonists of platelet activating factor," pp. 31-47.
Hirayama Naoki
Katou Tetsuya
Matsumoto Shu
Shibayama Katsuhiro
Jordan Kimberly
Toray Industries Inc.
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