Composition for suppressing infection and growth of human immuno

Details Composition for suppressing infection and growth of human immuno Composition for suppressing infection and growth of human immuno

1994-12-22

1998-03-10

Minnifield, Nita

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

514 6, 514 8, 514 12, 514 21, 530300, 530350, A01N 3718, A61K 3816, A61K 3800, C07K 200

Patent

active

057258643

ABSTRACT:
The invention relates to compositions and methods for inhibiting infection or suppressing growth of human immunodeficiency virus. The composition comprises, as an effective component, an iron-binding protein (e.g., lactoferrin, transferrin, ovotransferrin), a chemically modified compound of the iron-binding protein, or a hydrolyzed compound of the iron-binding protein. The effective components are safe and can be easily prepared from inexpensive raw materials. The composition can be orally administered, injected or applied to the skin, eye, ear, nose or used as a preparation for vagina affusion, mouth washing or suppositories, and can effectively inhibit infection or suppress growth of human immunodeficiency virus.

REFERENCES:
patent: 4448762 (1984-05-01), Richards et al.
patent: 4918008 (1990-04-01), Gauri
patent: 4977137 (1990-12-01), Nichols et al.
patent: 5164486 (1992-11-01), Tsunoo et al.
patent: 5198419 (1993-03-01), Ando et al.
patent: 5214028 (1993-05-01), Tomita et al.
Legrand D. et al., "Characterization and Localization of an Iron-Binding 18-kDa Glycopeptide isolated From the N-Terminal Half of Human Lactoferrin", Biochimica et Biophysica Acta, 787, 90-96 (1984).
Tani F. et al., "Isolation and Characterization of Opioid Antagonist Peptides Derived From Human Lactoferrin", Agric. Biol. Chem. 54, 1803-1810 (1990).
Saito H. et al., "Potent Bactericidal Activity of Bovine Lactoferrin Hydrolysate Produced by Heat Treatment at Acidic pH", J. Dairy Science, 74, 3724-3730 (1991).
Richie et al, J. Reproductive Immunology, 12(2):137-148, 1987.
Brock, Archives of Disease in Childhood, 55:417-421, 1980.
Esaguy et al. 1993. Scand. J. Immunol. 38:147-152.
Haynes. 1993. Science. 260:1279-1286.
Niu et al. 1993. J. Infect. Dis. 168:1490-501.
Fox. 1994. Bio/Technology 12:128.
Brock 1980. Archives of Diseases in Childhood 55:417-421.
Sandstrom et al. 1987. Drugs 34:372-390.
Koff et al 1988. Development and Testing of AIDS Vaccines. Science 241:426-432.
Schild et al. 1990. Modern Vaccines, Lancet vol. 335:1081-84.
Letvin. 1993. Vaccines Against Human Immuno-Deficiency Virus . . . New England J. Medicine 329(19):1400-1405.
Fuchs et al., "Association Between Immune Activation, Changes of Iron Metabolism and Anaemia in Patients With HIV Infection," Eur J Haematol, 50:90-94 (1993).
Kotler et al., "Enteral Alimentation and Repletion of Body Cell Mass in Malnourished Patients With Acquired Immunodeficiency Syndrome," Am J. Clin Nutr., 53:149-54 (1991).
Letendre, "The Importance of Iron in the Pathogenesis of Infection and Neoplasia," TIBS, 166-168 (Apr., 1985).
Miles et al., "Recombinant Human Granulocyte Colony-Stimulating Factor Increases Circulating Burst Forming Unit-Erythron and Red Blood Cell Production in Patients With Severe Human Immuno-deficiency Virus Infection",: Blood, 75:2137-2142 (1990).
Blumberg et al., "Iron and Iron Binding Proteins in Persistent Generalised Lymphadenopathy and Aids," The Lancet, p. 347 (Feb., 1984).

Affiliated with

Also associated with

Rating

Composition for suppressing infection and growth of human immuno does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Composition for suppressing infection and growth of human immuno, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition for suppressing infection and growth of human immuno will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-137212