Composition for solubilization of paclitaxel and preparation...

Details Composition for solubilization of paclitaxel and preparation... Composition for solubilization of paclitaxel and preparation...

2003-07-18

2011-12-13

Wax, Robert A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S401000, C514S741000, C514S765000, C514S786000

Reexamination Certificate

active

08075917

ABSTRACT:
The present invention relates to a paclitaxel composition and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4 to 90% by weight of at least one selected from the monoglycerides, 0.01 to 90% by weight of at least one oil and 0.01 to 20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4 to 90% by weight of at least one selected from the monoglycerides, 0.01 to 90% by weight of at least one emulsifier and 0.01 to 20% by weight of paclitaxel. The composition of the present invention is an effective paclitaxel delivery system since the composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.

REFERENCES:
patent: 6531139 (2003-03-01), Gao et al.
patent: 6538019 (2003-03-01), Nakajima et al.
patent: 2003/0059470 (2003-03-01), Muller
patent: 2006/0127420 (2006-06-01), Chung et al.
patent: 2006/0134144 (2006-06-01), Chung et al.
patent: 2006/0210622 (2006-09-01), Pace et al.
patent: 56-18914 (1981-02-01), None
patent: 62-294612 (1987-12-01), None
patent: 4-217912 (1992-08-01), None
patent: 6-509577 (1994-10-01), None
patent: 8-512301 (1996-12-01), None
patent: 8-512303 (1996-12-01), None
patent: 10-503750 (1998-04-01), None
patent: 2001-524990 (2001-04-01), None
patent: 2001-269115 (2001-10-01), None
patent: 2002-080399 (2002-03-01), None
patent: 2002-511099 (2002-04-01), None
patent: 2004-520398 (2004-07-01), None
patent: WO-93/02665 (1993-02-01), None
patent: WO-00/59482 (2000-10-01), None
patent: WO-00/74653 (2000-12-01), None
patent: WO 01/01960 (2001-01-01), None
patent: WO-01/21154 (2001-03-01), None
patent: WO 01/68139 (2001-09-01), None
patent: WO-01/68139 (2001-09-01), None
patent: WO-01/72299 (2001-10-01), None
patent: WO 02/13815 (2002-02-01), None
patent: WO 02/13815 (2002-02-01), None
patent: WO-02/056878 (2002-07-01), None
patent: WO 02/064132 (2002-08-01), None
patent: WO-02/64132 (2002-08-01), None
patent: WO 03/045357 (2003-06-01), None
patent: WO-03/053350 (2003-07-01), None
Sparreboom, et al., “Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine”Proc. Natl. Acad. Sci. USA94:2031-2035 (Mar. 1997).
Database WPI Week 200213, Thomson Scientific, London, UK; AN 2002-192770, XP002550012.

Affiliated with

Also associated with

Rating

Composition for solubilization of paclitaxel and preparation... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Composition for solubilization of paclitaxel and preparation..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition for solubilization of paclitaxel and preparation... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4264368