Composition for site specific detection of gastrointestinal dama

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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436 64, 436 94, 436811, 436813, A01N 4304, A61K 3170

Patent

active

06037330&

ABSTRACT:
Disclosed is a composition for the site-specific detection of gastrointestinal damage containing (a) a first disaccharide that does not degrade in the colon, small intestine or stomach; (b) a second disaccharide that degrades in the colon but does not degrade in the small intestine or stomach; and (c) a third disaccharide that degrades to its monosaccharides in the small intestine and not in the stomach. A method for the site-specific detection of gastrointestinal damage employing the composition of the invention is also disclosed.

REFERENCES:
patent: 5023072 (1991-06-01), Cheng
patent: 5605840 (1997-02-01), Meddings et al.
patent: 5620899 (1997-04-01), Meddings et al.
Cobden, I., et al., "Intestinal Permeability And Screening Tests For Coeliac Disease", Gut, 512-518 (1980).
Meddings, J.B., et al., "Sucrose Permeability: A Novel Means of Detecting Gastroduodenal Damage Noninvasively", Amer. J. Ther., 2 (11), 843-849 (1995).
Meddings, J.B. et al., "Sucrose: A Novel Permeability Marker For Gastroduodenal Disease", Gastroenterology, 104, 1619-26 (1993).
Sutherland, L., et al., "A Simple, Non-invasive Marker of Gastric Damage: Sucrose Permeability", The Lancet, 343, 998-1000 (1994).
Meddings, J., et al., "Noninvasive Detection of Nonsteroidal Anti-inflammatory Drug-Induced Gastropathy In Dogs"Am. J. Vet. Res., 56, 8, 997-981 (1995).
Menzies, I., "Absorption of Intact Oligosaccharide In Health And Disease", Biochemical Society Transactions 550th Meeting, Englefield Green, vol. 2, 1042-1047 (1974).

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