Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1984-11-28
1987-05-26
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514454, 514474, A61K 3578, A61K 3135, A61K 3134
Patent
active
046685162
DESCRIPTION:
BRIEF SUMMARY
This invention relates to a composition for regenerating the collagen of connective skin tissue.
Collagen is the main constituent (70% of the connective tissue) making up the supporting tissue of the organs, and particularly the skin.
Collagen consists of long elastic polypeptide fibres interconnected by bridges which provide the cohesion and stability of the connective tissue. This texture enables it to act as an elastic tissue in every direction and retain water, thus actively taking part in water control at the skin. Collagen ageing manifests itself as a break in the connections between the fibres. Age, severe weather, and pollution accelerate these breaks and slow down their renewal. Accordingly, the skin loses its elasticity and dehydrates. The resulting slackening of the skin causes ugly wrinkles and the like to form.
These disadvantages are not only concerned with aesthetics. The skin is not just a covering; it is an organ which has numerous properties which are essential to proper operation of the entire organism. For this purpose the skin has a highly developed vascular system which underlies exchanges which are essential to the performance of the various skin functions. The walls of the capillaries of this vascular system consist essentially of connective tissue. Its deterioration reduces the elasticity of the walls, thus modifying the pressure ratios between the arterial part and the venous part, which underlie the mechanism responsible for the arterial flow and the venous return, hence nutrition of the skin and the specific metabolisms of its activity.
Irrespective of the disorders that may result from the slowing down of the various skin functions, skin malnutrition is manifested by ageing of the skin, resulting from inadequate renewal of the old cells.
It is therefore doubly important to correct these functional deficiencies of the skin, since this affects physical health by renewing the physiological activity of the skin and it also affects mental health because of the aesthetic appearance of such correction.
The object of this invention is to provide a solution to the problem indicated hereinabove.
According to the invention, the composition for regenerating the collagen of the connective tissue of the skin, is characterised in that it contains an aqueous conifer bark extract buffered to a pH of about 7 containing water-soluble flavonols and vitamin C.
The flavonols extracted from the barks of conifers such as pine and cypress, have the following formula ##STR1## wherein R denotes a lower alkyl radical.
Applicant has surprisingly found that these flavonols have a positive action on regeneration of the collagen of the connective tissue.
It has also been found that the presence of vitamin C in the aqueous extract not only provides the organism with vitamin C but also potentiates the effects of the flavonols.
Flavonols extracted from conifer barks tend to polymerise readily thus losing their activity on collagen regeneration.
The presence of the buffer to give a pH of about 7 in the composition obviates this polymerization and enables the flavonols to be kept in solution, more particularly in the form of dimers, which are the most active.
Experiments carried out on animals have shown that the composition according to the invention diffuses perfectly into the skin and readily reaches not only the connective skin tissue but also the connective vascular tissue. Local application of the composition according to the invention is therefore perfectly suitable for the treatment of connective tissue deficiencies, giving a specific and complete correction thereof.
According to another aspect of the invention, the process for the preparation of the composition according to the invention comprises the following steps: which alcohol has been added, added and a buffer is added to keep the pH at a value of about 7, to keep the pH at a value of about 7, and then the solution is filtered and of step (b).
With this procedure appreciable quantities of flavonols are extracted while at the same time their polymeri
REFERENCES:
Stone, I. Healing Factor, Vitamin C Against Disease, 1974, Grosset and Dunlap, pp. 47 & 48.
"The Merck Index", Tenth Edition, p. 174, No. 1226, Ref. 1226, Quercitrin, Merck & Co., Inc. Rahway, N.J., 1983.
"Effect of Flavonols on Ascorbic Acid and Anthocyanintability in Model Systems", Chemical Abstracts, vol. 82, No. 13, Mar. 31, 1975, Colombus, Ohio, p. 389.
Duraffourd Alain
Duraffourd Jean-Max
Brown Johnnie R.
Rollins John W.
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