Composition for reducing serum cholesterol levels

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514724, 514739, A61K 31045

Patent

active

059523930

ABSTRACT:
A composition for reducing serum cholesterol in humans and animals is provided. The composition includes phytosterol and policosanol which together produce a synergistic effect in lowering serum cholesterol levels. Preferably the composition includes about 3.2:1 parts by weight of phytosterol and policosanol.

REFERENCES:
patent: 4391732 (1983-07-01), Lundmark
patent: 5502045 (1996-03-01), Miettinen et al.
patent: 5663156 (1997-09-01), Granja et al.
patent: 5770749 (1998-06-01), Kutney et al.
16(6): 723.
Arruzazabala, M.L. et al. "Effect of policosanol on cerebral ishemia in Mongolian gerbils: role of prostacyclin and thromboxane A2" Prostaglandin Leukot Essent Fatty Acids Sep. 1993;49(3):695-7.
Arruzazabala, M.L., et al. "Effects of policosanol on platelet aggregation in rats" Thromb Res Feb. 1, 1993;69(3):321-7.
Kabir, Y., et al. "Biodistribution and metabolism of orally administered octacosanol in rats" Ann Nutr Metab 1993;37(1):33-8.
Menendez, R. et al. "Cholesterol-lowering effect of policosanol on rabbits with hypercholesterolaemia induced by a wheat starch-casein diet" Br J Nutri Jun. 1997;77(6):923-32.
Arrazazabala M.L., et al. "Effect of policosanol successive dose increases on platelet aggregation in healthy volunteers" Pharmacol Res Nov.-Dec. 1996;34(5-6):181-5.
Valdes, S. et al. "Effect of policosanol on platelet aggregation in healthy volunteers" Int J Clin Pharmacol Res 1996;16(2-3):67-72.
Canetti, M. et al. "A two-year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinaemia" Int J Clin Pharmacol Res 1995;15(4):159-65.
Arruzazabala, M.L. et al. "Cholesterol-lowering effects of policosanol in rabbits" Biol Res 1994;27(3-4):205-8.
Menendez, R. et al. "Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts" Biol Res 1994;27(3-4):199-203.
Batista, J. et al. "Effect of policosanol on hyperlipidemia and coronary heart disease in middle-aged patients. A 14-month pilot study" Int J Clin Pharmacol Ther Mar. 1996;34(3):134-7.
Torres, O. et al. "Treatment of hypercholesterolemia in NIDDM with policosanol" Diabetes Care Mar. 1996;18(3):393-7.
Noa, M. "Effect of policosanol on isoprenaline-induced myocardial necrosis in rats" J Pharm Pharmacol Apr. 1994; 46(4):282-5.
Rodriguez-Echenique, C. et al. "Effects of policosanol chronically administered in male monkeys (Macaca arctoides)" Food Chem Toxicol Jun. 1994;32(6):565-75.
Aleman, C.L. et al. "A 12-month study of policosanol oral toxicity in Sprague Dawley rats" Toxicol Lett 1994 Jan. 1994;70(1):77-87.
Kato, S. et al. "Octacosanol affects lipid metabolism in rats fed on a high-fat diet." British Journal of Nutrition. v. 73, Mar. 1995, pp. 433-441.
Aleman, C.L. et al. "Carcinogenicity of policosanol in mice: an 18-month study." Food Chem Toxicol Jul. 1995 ;33(7):573-8.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Composition for reducing serum cholesterol levels does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Composition for reducing serum cholesterol levels, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition for reducing serum cholesterol levels will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1510335

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.