Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-11-29
1998-05-19
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 17, 530317, 530329, C07K 764, A61K 3702
Patent
active
057536198
ABSTRACT:
Cyclic hexapeptides having antagonistic activity on endothelin receptors of ##STR1## wherein X and Y each is an .alpha.-amino acid residue having D-, L-form or DL-form, A is a D-acidic-.alpha.-amino acid residue, B is a neutral-.alpha.-amino acid residue having D- or L-form, C is an L-.alpha.-amino acid residue and E is a D-.alpha.-amino acid residue having an aromatic ring group can be effectively used for prophylaxis and/or treatment of pulmonary circulatory diseases.
REFERENCES:
S.T. Bonvallet et al., American Journal of Physiology, vol. 266, H1327-H1331 (1994).
T. Miyauchi, et al., Circulation Research, "Contribution of Endogenous Endothelin-1 to the Progression of Cardiopulmonary Alterations in Rats With Monocrotaline-Induced Pulmonary Hypertension", vol. 73, No. 5, 887-897 (1993).
Kusumoto Keiji
Wakimasu Mitsuhiro
Watanabe Toshifumi
Borin Michael L.
Conlin David G.
Lowen Cara Z.
Takeda Chemical Insustries, Ltd.
Tsang Cecilia J.
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