Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-02-08
2005-02-08
Carlson, Karen Cochrane (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
06852692
ABSTRACT:
A composition for promoting extension of bladder smooth muscle, comprising adrenomedullin. The composition of the present invention may be used to ameliorate a urination disorder. The urination disorder may be a urinary incontinence selected from the group consisting of urge incontinence, reflex incontinence, and overflow incontinence. According to the present invention, a method is provided for ameliorating a urination disorder using a composition comprising adrenomedullin. Further, use of adrenomedullin in production of a drug for ameliorating a urination disorder is provided.
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Junji Nishimura et al, “The relaxant effect of adrenomedullin on particular smooth muscles despite a general expression of its mRNA in smooth muscle, endothelial and epithelial”, Br. J. Pharmacol. (1997), vol. 120, No. 2, pp. 193-200.
Carlson Karen Cochrane
Fay Sharpe Fagan Minnich & McKee LLP
Klein Richard M.
Shionogi & Co. Ltd.
Snedden Sheridan
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