Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-08-26
2008-03-25
Tate, Christopher (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S300000
Reexamination Certificate
active
07348306
ABSTRACT:
A composition for promoting lacrimal secretion which can be used safely and effectively in the lacrimal secretion promoting therapy, not in the conventional supplemental therapy of lacrimal fluid components is provided. The composition comprises a component which activates PAR-2. Also, a contact lens which retains and/or contains said composition for promoting lacrimal secretion is provided.
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Schechter, N.M. et al, “Corneal and Conjunctival Keratinocytes Contain Functional Protease-Activated Receptors,” Department of Dermatology, University of Pennsylvania, Philadelphia, Pa.
Nystedt, Sverker et al, “Molecular Cloning of a Potential Proteinase Activated Receptor,”Proc. Natl. Acad. Sci. USA,vol. 91, Sep. 1994, Medical Sciences, (pp. 9208-9212).
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Vergnolle, “Proteinase-activated receptor 2 (PAR-2)-activation peptides: identification of a receptor distinct from PAR-2 that regulates intestinal transport”, PNAS. (1998). 95:7766-7771.
Araki Hiromasa
Kawabata Atsufumi
Kawai Kenzo
Nishikawa Hiroyuki
Nishimura Sachiyo
Browdy and Neimark PLLC
Fuso Pharmaceutical Industries Ltd.
Tate Christopher
Teller Roy
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