Composition for preventing lactation or pregnancy in mammals and

Details Composition for preventing lactation or pregnancy in mammals and Composition for preventing lactation or pregnancy in mammals and

1972-12-18

1976-06-29

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602855, A61K 3148, C07D45702

Patent

active

039669416

ABSTRACT:
.alpha.-D-6-methylergolinyl-8-acetamides of the formula: ##SPC1##
Are readily prepared from .alpha.-D-6-methylergolinyl-8-acetic acid azide hydrochloride and amines of the formula R.sub.1 -NH-R.sub.2 and may be converted to their salts with inorganic and organic acids by neutralization. In these formulas, R.sub.1 may be hydrogen or lower alkyl, R.sub.2 may be hydrogen, lower alkyl, cycloalkyl having 5 or 6 carbon atoms, hydroxyalkyl having 3 or 4 carbon atoms, or lower alkoxycarbonylmethyl or R.sub.1 and R.sub.2 jointly may be divalent alkylene having 4 or 5 C atoms. The salts of most of these bases with physiologically tolerated acids are nontoxic in doses which suppress lactatical and prevent pregnancy in rats when applied orally after copulation. The others, equally non-toxic, extend the effective period of thiopental.

REFERENCES:
patent: 3583992 (1971-06-01), Hoffmann

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