Composition for pH dependent controlled release of active ingred

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills

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Details

424465, 424470, 424472, 514778, 536102, 536107, 536110, A61K 920, A61K 926, A61K 924, C08B 3102

Patent

active

056562926

ABSTRACT:
The present invention is related to a composition for pH dependent or pH regulated controlled release of active ingredients especially drugs. The composition consists of a compactible mixture of the active ingredient and starch molecules substituted with acetate and dicarboxylate residues. The preferred dicarboxylate acid is succinate. The average substitution degree of the acetate residue is at least 1 and 0.2-1.2 for the dicarboxylate residue. The starch molecules can have the acetate and dicarboxylate residues attached to the same starch molecule backbone or attached to separate starch molecule backbones. The present invention also discloses methods for preparing said starch acetate dicarboxylates by transesterification or mixing of starch acetates and starch dicarboxylates respectively.

REFERENCES:
patent: 4011392 (1977-03-01), Rudolph et al.
Pradeepkumar P. et al, "Evaluation of Preflo Modified Starches as New Direct Compression Excipients.", Pharmaceutical Research, vol. 10, No. 11, (1993).

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