Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1995-07-05
1997-08-12
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424465, 424470, 424472, 514778, 536102, 536107, 536110, A61K 920, A61K 926, A61K 924, C08B 3102
Patent
active
056562926
ABSTRACT:
The present invention is related to a composition for pH dependent or pH regulated controlled release of active ingredients especially drugs. The composition consists of a compactible mixture of the active ingredient and starch molecules substituted with acetate and dicarboxylate residues. The preferred dicarboxylate acid is succinate. The average substitution degree of the acetate residue is at least 1 and 0.2-1.2 for the dicarboxylate residue. The starch molecules can have the acetate and dicarboxylate residues attached to the same starch molecule backbone or attached to separate starch molecule backbones. The present invention also discloses methods for preparing said starch acetate dicarboxylates by transesterification or mixing of starch acetates and starch dicarboxylates respectively.
REFERENCES:
patent: 4011392 (1977-03-01), Rudolph et al.
Pradeepkumar P. et al, "Evaluation of Preflo Modified Starches as New Direct Compression Excipients.", Pharmaceutical Research, vol. 10, No. 11, (1993).
Nakari Leena Johanna
Paronen Timo Petteri
Peltonen Soili Hellevi
Urtti Arto Olavi
Vuorenpaa Jani-Emanuel
Alko Group Ltd.
Azpuru Carlos A.
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