Composition for nasal administration of desmopressin

Details Composition for nasal administration of desmopressin Composition for nasal administration of desmopressin

1995-04-25

1996-03-12

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3816, A61K 3821

Patent

active

054985986

ABSTRACT:
An aqueous composition for spray nasal administration of a synthetic analog of vasopressin (desmopressin; actate containing between 2.5 and 7.5 .mu.g per 100 .mu.l. The composition may additionally contain an osmotic-pressure controlling agent, such as sodium chloride, a preservative, such as chlorobutanol or benzalkonium chloride, and a buffer stabilizing the pH between about 4 and 6. Buffers containing citrate and/or phosphate are preferred. Also disclosed is a sealed container filled with the composition, an assembly comprising the container and a spray pump, and the use of the composition, the container, and the assembly in the management of urinary disorders.

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Vavra, Effect Of A Synthetic Analogue Of Vasopressin In Animals And In Patient With Diabetes Insipidue, Lancet, pp. 948-952 (1968).
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