Composition for medical use having improved water-solubility...

Details Composition for medical use having improved water-solubility... Composition for medical use having improved water-solubility...

2005-03-23

2010-12-21

Jones, D L (Department: 1618)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C424S001110, C424S001650, C530S300000, C530S327000, C530S328000, C530S329000

Reexamination Certificate

active

07854918

ABSTRACT:
By preliminarily dissolving a basic organic compound in an aqueous solvent in which a peptide usable in metal-labeling is to be dissolved, the solubility of the peptide is improved and thus metal-labeling can be carried out without heating. A composition for medical use containing a peptide usable in metal-labeling and a basic organic compound acceptable as a pharmaceutical additive can be utilized as a preparation useful in image diagnosis, radiotherapy and so on.

REFERENCES:
patent: 5891418 (1999-04-01), Sharma
patent: 7220827 (2007-05-01), Seki et al.
patent: 95/11045 (1995-04-01), None
Behr, T.M. et al., Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives, Cancer research, 1995, vol. 55, No. 17, p. 3825-34.
Verbeke, K. et al., Influence of the bifunctional chelate on the biological behavior of (99m)Tc-labeled chemotactic peptide conjugates, Nucl. Med. Biol., 2000, vol. 27, No. 8, p. 769-79.
Van Der Laken, C. J. et al., Technetium-99m-labeled Chemotactic Peptides in acute infection and sterile inflammation; The Journal of Nuclear Medicine, vol. 38, No. 8, Aug. 1997, p. 1310-1315.

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