Composition for macrophage activation

Details Composition for macrophage activation Composition for macrophage activation

1988-07-08

1990-08-21

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 88, 530322, A61K 3702, C07K 900

Patent

active

049506455

ABSTRACT:
The present invention provides a novel lipophilic dissacharide-tripeptide derivative of the known base compound muramyl dipeptide (MDP). The compound of the invention is preferably encapsulated into multilamellar liposomes, which can be formed from phosphatidyl choline and phosphatidyl glycerol. The compound is effective in activating human monocytes with subsequent destruction of tumor cells. The compound is also nontoxic in dosages well exceeding anticipated human dosages.

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